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new PDB depositions vs. their blind AlphaFold predictions — a running test of "is folding solved?"

26LM_A

E3 ubiquitin-protein ligase CBL-B · Q13191 · RCSB 26LM · AF-Q13191-F1 (v6)

0.7936

TM-score

0.8523

lDDT

20.526

Cα-RMSD Å

89.38

mean pLDDT

0.7117

FRAUD score

99.4%

novelty (max id)

Per-domain breakdown

Source	Domain	Range	Residues	TM	RMSD Å	mean Cα Δ	Name
PAE	PAE:1-982	1-982	396	0.2642	20.526	17.582

All metrics

Global fold agreement

TM-score (norm. experiment)	0.7936
TM-score (norm. model)	0.3269
TM-score (norm. shorter)	0.7936
TM-score (norm. longer)	0.3269
Cα-RMSD (Å)	20.526
backbone-RMSD (Å)	20.527
all-atom-RMSD (Å)	20.413
core-RMSD (Å)	0.733
core fraction	0.505
GDT_TS	7.26
GDT_HA	1.96
MaxSub	0.8863
structural overlap (3.5 Å)	0.0505

Local, superposition-free

lDDT	0.8523
contact-map Jaccard	0.7526
contact precision	0.8708
contact recall	0.8472
distance-matrix mean Δ (Å)	5.819
CAD-score (approx)	0.8572

Backbone & secondary structure

SS agreement Q3 (%)	95.2
mean Δφ (°)	13.6
mean Δψ (°)	15.3
torsion within 30° (frac)	0.8535
Rg experiment (Å)	22.37
Rg model (Å)	24.79
ΔRg (Å)	2.42

Confidence calibration

mean pLDDT	89.38
pLDDT↔lDDT Pearson	0.6718
pLDDT↔lDDT Spearman	0.6945
PAE↔observed Pearson	0.6713
PAE overconfident frac	0.0749
mean PAE (Å)	11.824
mean observed error (Å)	5.804

Context & headline

coverage of model	0.4033
coverage of experiment	1.0
seq identity aligned (%)	98.23
confidently-wrong residue frac	0.8864
FRAUD score	0.7117

Deposited 2026-05-06 · released 2026-06-17 · X-ray · 1.95 Å · closest pre-cutoff chain: 3ZNI_1