Release week 2025-03-26

Jump to:

217

structures analysed (15 full · 6.9%)

31.4%

confidently wrong

20.9%

novel sequences

10.5%

novel & wrong

0.82

median TM-score

⭐ This week's notable releases

2 novel sequences, 3 confidently wrong. Highlight: Spatacsin.

PDB	Protein	Flags	Why it matters
8YAD_B ↗	Spatacsin	novel · 100% confidently wrong	Genuinely unseen sequence (0% identity to anything AlphaFold trained on) — and AlphaFold got the fold wrong despite high confidence.
9BET_A ↗	Myeloid cell surface antigen CD33	novel · 100%	Genuinely unseen sequence (0% identity to anything AlphaFold trained on).
8UO5_D ↗	Immediate early response gene 5 protein	confidently wrong	A close pre-cutoff homolog existed (100% identity to 4CI1_2) yet AlphaFold confidently missed the fold.
8YAD_C ↗	Zinc finger FYVE domain-containing protein 26	confidently wrong	A close pre-cutoff homolog existed (36% identity to 2YQM_1) yet AlphaFold confidently missed the fold.

see all 217 structures ↓

Zoomed into the red "confidently wrong" box above (pLDDT ≥ 70, TM < 0.5) — the structures AlphaFold got confidently wrong.

The worst offenders ranked, one row per protein (AlphaFold has one model per sequence, so repeat depositions are collapsed — “×N” marks how many structures of that protein exist; the worst is shown). Each row joins what AlphaFold claimed (blue, pLDDT/100) to what the experiment showed (red, TM-score) — the longer the bar, the bigger the miss. Hover a dot to preview its Cα-deviation ribbon; click to open the full entry.

How to read this

Every point is one experimental protein structure. The horizontal axis is AlphaFold's own confidence in its prediction (mean pLDDT, 0–100). The vertical axis is how well that blind prediction actually matches the experiment (TM-score, 0–1; above 0.5 means the same fold, above 0.9 near-identical). Marker size grows with the FRAUD score (confidence-weighted error).

Cutoff: the shaded red box is the "confidently wrong" zone — AlphaFold was confident (mean pLDDT above 70) yet the fold is wrong (TM-score below 0.5). A predictor that had truly solved folding would leave that box empty.

Take-home: 3 of 217 structures (1.4%) are confidently wrong; median TM-score is 0.82.

Read moreShow less — how each metric is calculated

TM-score: how similar the two 3D shapes are overall, 0–1 (a random pair scores ~0.17, an identical fold ~1). Length-normalised so large and small proteins compare fairly. TM = (1/L) Σᵢ 1/(1 + (dᵢ/d₀)²) — dᵢ is the gap between the i-th aligned Cα atoms after best-fit superposition, and d₀ = 1.24(L−15)^⅓ − 1.8 sets the distance scale for length L. Ref: Zhang & Skolnick, Proteins 2004 doi:10.1002/prot.20264; computed with TM-align, doi:10.1093/nar/gki524.

pLDDT: AlphaFold's own confidence in each residue, 0–100 (higher = surer). It is the model predicting its own accuracy before ever seeing the experiment. We plot the per-structure mean. pLDDT = (1/N) Σᵢ pLDDTᵢ, where pLDDTᵢ is the network's confidence output for residue i.

FRAUD score: the headline number — how wrong the prediction was, weighted by how confident AlphaFold was, so a big error it was sure about counts most. FRAUD = (1/N) Σᵢ (pLDDTᵢ/100) · min(Δᵢ,15)/15, where Δᵢ is residue i's Cα distance from the experiment (Å) after superposition, capped at 15 Å. Runs 0 (perfect) to 1.

Novelty: how little AlphaFold had to go on — 100 minus the highest sequence identity between this protein and any structure released before the 2018-04-30 training cutoff. High = genuinely unseen (100% = nothing similar was ever in the training set). novelty = 100 − maxₚ identity(s, p) over pre-cutoff PDB chains p, with identity = 100 × (matching aligned residues)/(alignment length), from an MMseqs2 search.

Homology: the point colour. High novelty (above 70%) flags the sequence as novel (amber) — AlphaFold had no close template; otherwise a pre-cutoff homolog existed (blue) it could have learned the fold from. novel ⇔ novelty > 70%.

What the metrics mean

TM-score (0–1): overall fold match — above 0.5 is the same fold, above 0.9 near-identical. Cα-RMSD (Å): average backbone distance after best-fit superposition — lower is better (under 2 Å is excellent). lDDT (0–1): local accuracy measured without superposition — above 0.8 is good. Each bar counts how many structures fall in that range.

Take-home: median TM-score 0.82 — most predictions match the experimental fold well, with a long tail that do not.

Read moreShow less — how each metric is calculated

TM-score: overall shape match, 0–1 (above 0.5 = same fold, above 0.9 near-identical), length-normalised. TM = (1/L) Σᵢ 1/(1 + (dᵢ/d₀)²) with dᵢ the aligned-Cα gap after superposition and d₀ = 1.24(L−15)^⅓ − 1.8. Ref: Zhang & Skolnick, Proteins 2004 doi:10.1002/prot.20264.

Cα-RMSD: the average straight-line distance between matching backbone Cα atoms once the two structures are best-fit superposed (Å; lower is better, under ~2 Å excellent). RMSD = √( (1/N) Σᵢ |Pᵢ − (R·Qᵢ + t)|² ), with Pᵢ/Qᵢ the experimental/model Cα coordinates and R,t the rotation and translation from Kabsch superposition.

lDDT: local accuracy with no superposition — the fraction of short-range inter-residue distances the model reproduces, so it is not fooled by a single wrongly-placed domain. lDDT = (1/N) Σᵢ ¼ Σ_t 1[ |d_exp − d_model| < t ] over thresholds t ∈ {0.5, 1, 2, 4} Å and all residue pairs within 15 Å.

Trend over time

The blue line is the mean TM-score of the structures by their deposit month; the red bars count how many were confidently wrong. Binning by deposit date (rather than by when we processed them) gives an even timeline, tracking whether AlphaFold's accuracy on newly-deposited structures is holding steady, improving, or slipping as the PDB keeps growing. Months with fewer than 5 structures are omitted so each point is a meaningful average. A dashed trend line is drawn only if the change over time is statistically significant.

Read moreShow less — how each metric is calculated

Mean TM-score: the month's average shape-match score. TM̄ = (1/M) Σ TM over the M structures deposited that month.

Trend line: a monotonic-trend test over the monthly means — Mann-Kendall (Kendall's τ) for significance, with a robust Theil-Sen slope for the line. Rank-based, so it tolerates the skewed TM distribution and noisy low-count months. Shown only when p < 0.05; otherwise a note reports that no significant trend was found.

Confidently wrong: the count that were both confident and wrong. count( mean pLDDT > 70 AND TM < 0.5 ).

Matched structures

PDB	UniProt	Protein	Method	Å	Deposited	Novelty %	pLDDT	TM	lDDT	GDT_TS	RMSD	FRAUD	Flag
8YSZ_A	P06213	Isoform Short of Insulin receptor	EM	3.38	2024-03-24	0.20	87.85	0.51	0.83	0.13	18.66	0.83	ok
8UO5_D	Q5VY09	Immediate early response gene 5 protein	EM	3.27	2023-10-19	0.00	84.91	0.36	0.42	2.91	17.39	0.73	wrong
8YAD_B	Q96JI7	Spatacsin	EM	4.02	2024-02-08	100.00 novel	72.72	0.37	0.69	0.00	93.41	0.73	wrong
8YAD_C	Q68DK2	Zinc finger FYVE domain-containing protein	EM	4.02	2024-02-08	63.50	72.23	0.37	0.69	0.00	86.61	0.72	wrong
8REW_A	P01137	Transforming growth factor beta-1	EM	2.98	2023-12-12	0.90	87.64	0.70	0.78	8.69	20.02	0.64	ok
9JB2_A	P05067	Amyloid-beta precursor protein	EM	2.90	2024-08-26	0.00	52.55	0.34	0.43	5.88	13.27	0.38	ok
9JB0_A	P05067	Amyloid-beta precursor protein	EM	2.90	2024-08-26	0.00	52.55	0.25	0.42	9.56	13.59	0.38	ok
9JB1_FF	P05067	Amyloid-beta precursor protein	EM	2.50	2024-08-26	0.00	52.55	0.28	0.41	9.56	13.62	0.38	ok
9JAZ_A	P05067	Amyloid-beta precursor protein	EM	3.00	2024-08-26	0.00	52.55	0.25	0.42	9.56	13.64	0.38	ok
9BET_A	P20138	Myeloid cell surface antigen CD33	NMR	—	2024-04-16	100.00 novel	67.73	0.54	0.55	20.83	9.44	0.29	ok
9B3A_A	P10636	Microtubule-associated protein tau	EM	3.20	2024-03-18	0.00	63.68	0.19	0.55	35.71	6.07	0.22	ok
9B3C_A	P10636	Microtubule-associated protein tau	EM	2.95	2024-03-18	0.00	63.68	0.28	0.58	38.10	5.97	0.21	ok
9E2Z_5	P33992	DNA replication licensing factor MCM5	EM	2.60	2024-10-23	—	78.06	0.75	—	—	—	0.20	ok
9E2Z_6	Q14566	DNA replication licensing factor MCM6	EM	2.60	2024-10-23	—	76.44	0.74	—	—	—	0.20	ok
9DQZ_M	P98155	Very low-density lipoprotein receptor	EM	2.90	2024-09-24	38.20	74.81	0.62	0.90	46.47	4.35	0.19	ok
9MQ6_A	P55072	Transitional endoplasmic reticulum ATPase	EM	3.30	2025-01-02	—	82.56	0.78	—	—	—	0.18	ok
9DIL_A	P55072	Transitional endoplasmic reticulum ATPase	EM	3.30	2024-09-05	—	82.56	0.79	—	—	—	0.17	ok
9HHQ_A	Q8TF71	Monocarboxylate transporter 10	EM	3.50	2024-11-22	—	81.88	0.79	—	—	—	0.17	ok
9B4Y_B	P52292	Importin subunit alpha-1	EM	3.74	2024-03-21	0.00	49.68	0.50	0.63	34.88	5.99	0.17	ok
8YSZ_C	P01344	Insulin-like growth factor II	EM	3.38	2024-03-24	—	59.03	0.72	—	—	—	0.16	ok
7H9N_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.35	2024-07-10	—	85.19	0.81	—	—	—	0.16	ok
7HBQ_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.73	2024-07-10	—	85.19	0.81	—	—	—	0.16	ok
7HBM_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.21	2024-07-10	—	85.19	0.81	—	—	—	0.16	ok
7HA8_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.22	2024-07-10	—	85.19	0.81	—	—	—	0.16	ok
7HB8_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.85	2024-07-10	—	85.19	0.81	—	—	—	0.16	ok
7HBJ_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.65	2024-07-10	—	85.19	0.81	—	—	—	0.16	ok
7HBX_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.25	2024-07-10	—	85.19	0.81	—	—	—	0.16	ok
7HB7_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.98	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HA9_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.00	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HAC_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.68	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HB3_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.34	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7H9Y_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.11	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HAV_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.45	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7H9T_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.48	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HBH_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.80	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HAP_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.35	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HAE_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.73	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HC0_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.66	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HAK_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.72	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HA3_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.98	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HBA_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.15	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7H9Z_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.06	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7H9O_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.55	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HBO_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.07	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HBK_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.14	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HB2_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.67	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HAL_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.65	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HAF_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.61	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7H9W_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.64	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HAT_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.04	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HC1_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.13	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HAR_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.77	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HAH_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.60	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HB4_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.87	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7H9V_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.52	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HBZ_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.44	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HAS_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.08	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HAA_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.67	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HC3_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.22	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HAX_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.29	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HAY_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.27	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HAJ_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.57	2024-07-10	—	85.19	0.82	—	—	—	0.16	ok
7HBU_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.44	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HA6_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.80	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HBW_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.91	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HBV_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.56	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HA2_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.73	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7H9L_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.42	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HAU_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.75	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HBP_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.91	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HBN_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.99	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HA4_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.61	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7H9X_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.47	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HAB_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.50	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HA5_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.53	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7H9M_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.49	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HB9_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.89	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HB0_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.78	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HAN_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.61	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HBY_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.82	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HBT_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.38	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HBR_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.91	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HBC_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.86	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HB1_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.66	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HAZ_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.68	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HAO_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.83	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HAI_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.65	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HAD_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.59	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HBS_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.38	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HBB_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.84	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HAQ_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.55	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HBE_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.79	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HB6_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.09	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HA1_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.46	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HB5_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.80	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HAM_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.77	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HAG_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.53	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7H9U_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.94	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HAW_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.65	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7H9S_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.17	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7H9P_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.64	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HBD_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.80	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7H9Q_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.51	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HBL_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.65	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HBF_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.97	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HA7_A	P07900	Heat shock protein HSP 90-alpha	X-ray	2.27	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7H9K_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.66	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HBG_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.69	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HA0_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.47	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7HC2_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.60	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
7H9R_A	P07900	Heat shock protein HSP 90-alpha	X-ray	1.69	2024-07-10	—	85.19	0.82	—	—	—	0.15	ok
9EBO_R	P43220	Glucagon-like peptide 1 receptor	EM	3.13	2024-11-12	—	81.50	0.82	—	—	—	0.14	ok
9EOS_A	P02768	Albumin	X-ray	2.10	2024-03-15	—	92.69	0.85	—	—	—	0.14	ok
9EOD_A	P02768	Albumin	X-ray	1.90	2024-03-14	—	92.69	0.86	—	—	—	0.13	ok
8YAH_D	Q96JI7	Spatacsin	EM	3.30	2024-02-09	—	66.75	0.82	—	—	—	0.12	ok
8YAB_D	Q96JI7	Spatacsin	EM	3.26	2024-02-08	—	66.75	0.82	—	—	—	0.12	ok
9EBN_A	P63092	Guanine nucleotide-binding protein G(s) su	EM	3.44	2024-11-12	—	91.31	0.87	—	—	—	0.12	ok
9B89_A	P55265	Maltodextrin-binding protein,Double-strand	EM	3.87	2024-03-29	—	68.38	0.83	—	—	—	0.12	ok
9EBO_A	P63092	Guanine nucleotide-binding protein G(s) su	EM	3.13	2024-11-12	—	91.31	0.87	—	—	—	0.12	ok
9EBQ_A	P63092	Guanine nucleotide-binding protein G(s) su	EM	3.16	2024-11-12	—	91.31	0.87	—	—	—	0.12	ok
9E2Z_3	P25205	Isoform 2 of DNA replication licensing fac	EM	2.60	2024-10-23	—	74.12	0.84	—	—	—	0.12	ok
9E2Z_2	P49736	DNA replication licensing factor MCM2	EM	2.60	2024-10-23	—	76.25	0.85	—	—	—	0.12	ok
9EBN_G	P59768	Guanine nucleotide-binding protein G(I)/G(	EM	3.44	2024-11-12	—	89.56	0.87	—	—	—	0.11	ok
9B4Y_A	Q14974	Importin subunit beta-1	EM	3.74	2024-03-21	—	94.81	0.88	—	—	—	0.11	ok
9CO5_B	Q15691	Microtubule-associated protein RP/EB famil	X-ray	2.77	2024-07-16	—	80.38	0.88	—	—	—	0.10	ok
9EBQ_G	P59768	Guanine nucleotide-binding protein G(I)/G(	EM	3.16	2024-11-12	—	89.56	0.90	—	—	—	0.09	ok
9EBO_G	P59768	Guanine nucleotide-binding protein G(I)/G(	EM	3.13	2024-11-12	—	89.56	0.90	—	—	—	0.09	ok
9E2Z_A	Q14691	DNA replication complex GINS protein PSF1	EM	2.60	2024-10-23	—	93.00	0.91	—	—	—	0.08	ok
9E2Z_4	P33991	DNA replication licensing factor MCM4	EM	2.60	2024-10-23	—	73.56	0.89	—	—	—	0.08	ok
8UO5_C	P67775	Serine/threonine-protein phosphatase 2A ca	EM	3.27	2023-10-19	—	95.06	0.92	—	—	—	0.07	ok
9CSK_B	P11802	Cyclin-dependent kinase 4	X-ray	2.25	2024-07-24	—	86.81	0.92	—	—	—	0.07	ok
9E2Z_C	Q9BRX5	DNA replication complex GINS protein PSF3	EM	2.60	2024-10-23	—	87.44	0.92	—	—	—	0.07	ok
8YAH_C	Q9NUS5	AP-5 complex subunit sigma-1	EM	3.30	2024-02-09	—	80.44	0.91	—	—	—	0.07	ok
8YAB_C	Q9NUS5	AP-5 complex subunit sigma-1	EM	3.26	2024-02-08	—	80.44	0.91	—	—	—	0.07	ok
8UO5_B	P63151	Serine/threonine-protein phosphatase 2A 55	EM	3.27	2023-10-19	—	92.31	0.93	—	—	—	0.07	ok
8UO5_A	P30153	Serine/threonine-protein phosphatase 2A 65	EM	3.27	2023-10-19	—	94.94	0.93	—	—	—	0.07	ok
9B81_A	O75874	Isocitrate dehydrogenase [NADP] cytoplasmi	X-ray	2.56	2024-03-28	—	95.88	0.93	—	—	—	0.06	ok
9GFK_A	Q00987	E3 ubiquitin-protein ligase Mdm2	X-ray	1.84	2024-08-09	—	62.59	0.90	—	—	—	0.06	ok
9MQ6_C	Q96JH7	Deubiquitinating protein VCPIP1	EM	3.30	2025-01-02	—	69.38	0.92	—	—	—	0.05	ok
9EJH_C	P04233	HLA class II histocompatibility antigen ga	X-ray	2.45	2024-11-27	—	46.29	0.34	0.90	70.83	1.79	0.05	ok
8YQ1_A	O15520	Fibroblast growth factor 10	X-ray	2.56	2024-03-18	—	80.00	0.94	—	—	—	0.05	ok
9CVC_A	Q8IWY9	Codanin-1	EM	3.50	2024-07-29	—	71.38	0.93	—	—	—	0.05	ok
9JE5_A	Q8NET8	Transient receptor potential cation channe	EM	3.53	2024-09-02	—	76.50	0.94	—	—	—	0.04	ok
9N1T_A	P53355	Death-associated protein kinase 1	X-ray	1.43	2025-01-27	—	82.56	0.95	—	—	—	0.04	ok
9EPF_A	Q50LE5	Capsid protein precursor	EM	3.54	2024-03-18	—	81.34	0.95	—	—	—	0.04	ok
9JEG_A	Q8NET8	Transient receptor potential cation channe	EM	3.39	2024-09-03	—	76.50	0.94	—	—	—	0.04	ok
9E2Z_7	P33993	DNA replication licensing factor MCM7	EM	2.60	2024-10-23	—	80.44	0.95	—	—	—	0.04	ok
8YYM_A	Q99836	Myeloid differentiation primary response p	EM	3.30	2024-04-04	—	80.56	0.95	—	—	—	0.04	ok
9EBN_R	P43220	Glucagon-like peptide 1 receptor	EM	3.44	2024-11-12	—	81.50	0.95	—	—	—	0.04	ok
8YAH_B	Q2VPB7	AP-5 complex subunit beta-1	EM	3.30	2024-02-09	—	79.81	0.95	—	—	—	0.04	ok
8YAB_B	Q2VPB7	AP-5 complex subunit beta-1	EM	3.26	2024-02-08	—	79.81	0.95	—	—	—	0.04	ok
9E2Z_B	Q9Y248	DNA replication complex GINS protein PSF2	EM	2.60	2024-10-23	—	93.12	0.96	—	—	—	0.04	ok
9DIL_C	Q96JH7	Deubiquitinating protein VCPIP1	EM	3.30	2024-09-05	—	69.38	0.95	—	—	—	0.04	ok
9E2Z_D	Q9BRT9	DNA replication complex GINS protein SLD5	EM	2.60	2024-10-23	—	90.38	0.96	—	—	—	0.04	ok
9GW0_A	P29373	Cellular retinoic acid-binding protein 2	X-ray	2.40	2024-09-26	—	96.75	0.96	—	—	—	0.04	ok
9GVZ_A	P29373	Cellular retinoic acid-binding protein 2	X-ray	3.00	2024-09-26	—	96.75	0.96	—	—	—	0.04	ok
9EN3_A	Q8N8M0	Probable N-acetyltransferase 16	X-ray	1.40	2024-03-12	—	87.50	0.96	—	—	—	0.04	ok
9GVX_A	P29373	Cellular retinoic acid-binding protein 2	X-ray	2.10	2024-09-26	—	96.75	0.96	—	—	—	0.03	ok
9CSK_A	P24385	G1/S-specific cyclin-D1	X-ray	2.25	2024-07-24	—	87.31	0.96	—	—	—	0.03	ok
9EJH_A	P01909	HLA class II histocompatibility antigen, D	X-ray	2.45	2024-11-27	—	87.94	0.96	—	—	—	0.03	ok
9DQV_M	Q9P2E7	Protocadherin-10	EM	3.30	2024-09-24	—	73.19	0.95	—	—	—	0.03	ok
9GVY_A	P29373	Cellular retinoic acid-binding protein 2	X-ray	2.05	2024-09-26	—	96.75	0.97	—	—	—	0.03	ok
8X7H_A	Q8IVV7	Glucose-induced degradation protein 4 homo	X-ray	2.90	2023-11-24	—	74.38	0.96	—	—	—	0.03	ok
9JEF_A	Q8NET8	Transient receptor potential cation channe	EM	3.62	2024-09-03	—	76.50	0.96	—	—	—	0.03	ok
8VDV_B	Q8NBP7	Proprotein convertase subtilisin/kexin typ	X-ray	1.97	2023-12-18	—	85.19	0.96	—	—	—	0.03	ok
9CO5_A	P62942	Peptidyl-prolyl cis-trans isomerase FKBP1A	X-ray	2.77	2024-07-16	—	96.25	0.97	—	—	—	0.03	ok
9EJI_B	A0A0U5IHY9	HLA class II histocompatibility antigen DQ	X-ray	2.20	2024-11-27	—	85.62	0.97	—	—	—	0.03	ok
9EBQ_R	P43220	Glucagon-like peptide 1 receptor	EM	3.16	2024-11-12	—	81.50	0.97	—	—	—	0.03	ok
9EJG_A	P01909	HLA class II histocompatibility antigen, D	X-ray	2.20	2024-11-27	—	87.94	0.97	—	—	—	0.03	ok
9DCW_A	P62942	Peptidyl-prolyl cis-trans isomerase FKBP1A	X-ray	1.72	2024-08-27	—	96.25	0.97	—	—	—	0.03	ok
9JEE_A	Q8NET8	Transient receptor potential cation channe	EM	3.51	2024-09-03	—	76.50	0.97	—	—	—	0.03	ok
8YYU_A	P42224	Signal transducer and activator of transcr	EM	3.84	2024-04-04	—	87.25	0.97	—	—	—	0.03	ok
9B84_A	P55265	Maltodextrin-binding protein,Double-strand	EM	3.20	2024-03-28	—	68.38	0.96	—	—	—	0.03	ok
8YYV_A	P42224	Signal transducer and activator of transcr	EM	3.07	2024-04-04	—	87.25	0.97	—	—	—	0.03	ok
8X7G_A	Q8IVV7	Glucose-induced degradation protein 4 homo	X-ray	2.70	2023-11-24	—	74.38	0.97	—	—	—	0.03	ok
9MRE_A	O14744	Protein arginine N-methyltransferase 5	X-ray	2.25	2025-01-07	—	93.31	0.97	—	—	—	0.03	ok
9EJI_A	Q08AS3	HLA class II histocompatibility antigen DQ	X-ray	2.20	2024-11-27	—	85.81	0.97	—	—	—	0.02	ok
9DYA_A	Q9UNE7	E3 ubiquitin-protein ligase CHIP	X-ray	1.89	2024-10-13	—	89.31	0.97	—	—	—	0.02	ok
9EN9_A	P00918	Carbonic anhydrase 2	X-ray	2.02	2024-03-12	—	97.38	0.98	—	—	—	0.02	ok
9EMT_A	Q8N8M0	Probable N-acetyltransferase 16	X-ray	1.40	2024-03-11	—	87.50	0.97	—	—	—	0.02	ok
9D8U_A	Q00534	Cyclin-dependent kinase 6	X-ray	2.00	2024-08-20	—	85.38	0.97	—	—	—	0.02	ok
9CVC_C	Q9Y294	Histone chaperone ASF1A	EM	3.50	2024-07-29	—	84.12	0.97	—	—	—	0.02	ok
9E2Z_E	O75419	Cell division control protein 45 homolog	EM	2.60	2024-10-23	—	92.56	0.98	—	—	—	0.02	ok
9EJG_B	O19712	MHC class II HLA-DQ-beta-1	X-ray	2.20	2024-11-27	—	89.69	0.98	—	—	—	0.02	ok
8REW_E	Q14392	Transforming growth factor beta activator	EM	2.98	2023-12-12	—	86.06	0.97	—	—	—	0.02	ok
9EJH_B	O19712	MHC class II HLA-DQ-beta-1	X-ray	2.45	2024-11-27	—	89.69	0.98	—	—	—	0.02	ok
9B83_A	P55265	Maltodextrin-binding protein,Double-strand	EM	3.01	2024-03-28	—	68.38	0.97	—	—	—	0.02	ok
9JDM_A	Q8NET8	Transient receptor potential cation channe	EM	3.13	2024-08-31	—	76.50	0.98	—	—	—	0.02	ok
8YQB_A	Q05315	Galectin-10	X-ray	1.95	2024-03-19	—	97.06	0.98	—	—	—	0.02	ok
9DYB_A	Q9UNE7	E3 ubiquitin-protein ligase CHIP	X-ray	1.60	2024-10-13	—	89.31	0.98	—	—	—	0.01	ok
9GIO_B	Q15369	Isoform 2 of Elongin-C	X-ray	1.49	2024-08-19	—	89.81	0.98	—	—	—	0.01	ok
8QJU_A	P16885	1-phosphatidylinositol 4,5-bisphosphate ph	EM	3.50	2023-09-13	—	83.38	0.98	—	—	—	0.01	ok
9GIO_C	P40337	von Hippel-Lindau disease tumor suppressor	X-ray	1.49	2024-08-19	—	84.44	0.99	—	—	—	0.01	ok
8X7H_B	O60885	Bromodomain-containing protein 4	X-ray	2.90	2023-11-24	—	55.31	0.98	—	—	—	0.01	ok
9GIO_A	Q15370	Elongin-B	X-ray	1.49	2024-08-19	—	92.50	0.99	—	—	—	0.01	ok
9MRE_B	Q9BQA1	Methylosome protein 50	X-ray	2.25	2025-01-07	—	91.00	0.99	—	—	—	0.01	ok
8X7G_B	O60885	Bromodomain-containing protein 4	X-ray	2.70	2023-11-24	—	55.31	0.98	—	—	—	0.01	ok
9EBO_B	P62873	Guanine nucleotide-binding protein G(I)/G(	EM	3.13	2024-11-12	—	97.06	0.99	—	—	—	0.01	ok
9LYG_A	P62942	Peptidyl-prolyl cis-trans isomerase FKBP1A	X-ray	1.26	2025-02-20	—	96.25	0.99	—	—	—	0.01	ok
9EBN_B	P62873	Guanine nucleotide-binding protein G(I)/G(	EM	3.44	2024-11-12	—	97.06	0.99	—	—	—	0.01	ok
9EBQ_B	P62873	Guanine nucleotide-binding protein G(I)/G(	EM	3.16	2024-11-12	—	97.06	0.99	—	—	—	0.01	ok
9BR3_A	P04637	Cellular tumor antigen p53	X-ray	1.90	2024-05-10	—	75.06	0.99	—	—	—	0.01	ok
8YQO_A	Q16850	Lanosterol 14-alpha demethylase	EM	3.52	2024-03-19	—	90.44	0.99	—	—	—	0.01	ok
8VDV_A	Q8NBP7	Proprotein convertase subtilisin/kexin typ	X-ray	1.97	2023-12-18	—	85.19	0.99	—	—	—	0.01	ok
7EDQ_A	P14174	Macrophage migration inhibitory factor	X-ray	1.27	2021-03-16	—	98.56	0.99	—	—	—	0.01	ok
9EP2_AAA	P00915	Carbonic anhydrase 1	X-ray	1.47	2024-03-16	—	96.81	0.99	—	—	—	0.01	ok
7EE8_A	P14174	Macrophage migration inhibitory factor	X-ray	1.22	2021-03-17	—	98.56	0.99	—	—	—	0.01	ok
8YQA_A	Q05315	Galectin-10	X-ray	2.17	2024-03-19	—	97.06	0.99	—	—	—	0.01	ok
9FEG_A	Q460N3	Protein mono-ADP-ribosyltransferase PARP15	X-ray	1.75	2024-05-20	—	79.06	0.99	—	—	—	0.00	ok
9DOZ_A	Q99972	Myocilin	X-ray	1.45	2024-09-20	—	78.94	0.99	—	—	—	0.00	ok
8YQC_A	Q05315	Galectin-10	X-ray	1.92	2024-03-19	—	97.06	1.00	—	—	—	0.00	ok
9QFV_A	P20231	Tryptase beta-2	X-ray	2.06	2025-03-12	—	91.31	0.99	—	—	—	0.00	ok
9EN8_A	P00918	Carbonic anhydrase 2	X-ray	1.10	2024-03-12	—	97.38	1.00	—	—	—	0.00	ok
9FDB_A	P17931	Galectin-3	X-ray	1.45	2024-05-16	—	73.81	0.99	—	—	—	0.00	ok
9LO7_A	Q08499	3',5'-cyclic-AMP phosphodiesterase 4D	X-ray	2.20	2025-01-22	—	67.44	0.99	—	—	—	0.00	ok
9FDC_A	P17931	Galectin-3	X-ray	1.78	2024-05-16	—	73.81	1.00	—	—	—	0.00	ok
9QFU_A	P20231	Tryptase beta-2	X-ray	1.98	2025-03-12	—	91.31	1.00	—	—	—	0.00	ok

Click a column header to sort. FRAUD = confidence-weighted error; a structure is flagged confidently wrong when mean pLDDT > 70 yet TM-score < 0.5.