Release week 2023-05-03

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195

structures analysed (29 full · 14.9%)

52.6%

confidently wrong

42.1%

novel sequences

10.5%

novel & wrong

0.934

median TM-score

⭐ This week's notable releases

4 novel sequences, 5 confidently wrong. Highlight: THO complex subunit 7 homolog.

PDB	Protein	Flags	Why it matters
7ZNK_G ↗	THO complex subunit 7 homolog	novel · 100% confidently wrong	Genuinely unseen sequence (0% identity to anything AlphaFold trained on) — and AlphaFold got the fold wrong despite high confidence.
7XJJ_C ↗	Galanin	novel · 100%	Genuinely unseen sequence (0% identity to anything AlphaFold trained on).
7VPX_C ↗	Splicing factor 3A subunit 3	novel · 74%	Genuinely unseen sequence (26% identity to anything AlphaFold trained on).
7VPX_E ↗	Probable ATP-dependent RNA helicase DDX46	confidently wrong	A close pre-cutoff homolog existed (41% identity to 4LJY_1) yet AlphaFold confidently missed the fold.
7VPX_B ↗	Splicing factor 3A subunit 2	novel · 72%	Genuinely unseen sequence (28% identity to anything AlphaFold trained on).
8GFT_C ↗	Hsp90 co-chaperone Cdc37, N-terminally processed	confidently wrong	A close pre-cutoff homolog existed (100% identity to 5FWK_2) yet AlphaFold confidently missed the fold.

see all 195 structures ↓

Zoomed into the red "confidently wrong" box above (pLDDT ≥ 70, TM < 0.5) — the structures AlphaFold got confidently wrong.

The worst offenders ranked, one row per protein (AlphaFold has one model per sequence, so repeat depositions are collapsed — “×N” marks how many structures of that protein exist; the worst is shown). Each row joins what AlphaFold claimed (blue, pLDDT/100) to what the experiment showed (red, TM-score) — the longer the bar, the bigger the miss. Hover a dot to preview its Cα-deviation ribbon; click to open the full entry.

How to read this

Every point is one experimental protein structure. The horizontal axis is AlphaFold's own confidence in its prediction (mean pLDDT, 0–100). The vertical axis is how well that blind prediction actually matches the experiment (TM-score, 0–1; above 0.5 means the same fold, above 0.9 near-identical). Marker size grows with the FRAUD score (confidence-weighted error).

Cutoff: the shaded red box is the "confidently wrong" zone — AlphaFold was confident (mean pLDDT above 70) yet the fold is wrong (TM-score below 0.5). A predictor that had truly solved folding would leave that box empty.

Take-home: 5 of 195 structures (2.6%) are confidently wrong; median TM-score is 0.934.

Read moreShow less — how each metric is calculated

TM-score: how similar the two 3D shapes are overall, 0–1 (a random pair scores ~0.17, an identical fold ~1). Length-normalised so large and small proteins compare fairly. TM = (1/L) Σᵢ 1/(1 + (dᵢ/d₀)²) — dᵢ is the gap between the i-th aligned Cα atoms after best-fit superposition, and d₀ = 1.24(L−15)^⅓ − 1.8 sets the distance scale for length L. Ref: Zhang & Skolnick, Proteins 2004 doi:10.1002/prot.20264; computed with TM-align, doi:10.1093/nar/gki524.

pLDDT: AlphaFold's own confidence in each residue, 0–100 (higher = surer). It is the model predicting its own accuracy before ever seeing the experiment. We plot the per-structure mean. pLDDT = (1/N) Σᵢ pLDDTᵢ, where pLDDTᵢ is the network's confidence output for residue i.

FRAUD score: the headline number — how wrong the prediction was, weighted by how confident AlphaFold was, so a big error it was sure about counts most. FRAUD = (1/N) Σᵢ (pLDDTᵢ/100) · min(Δᵢ,15)/15, where Δᵢ is residue i's Cα distance from the experiment (Å) after superposition, capped at 15 Å. Runs 0 (perfect) to 1.

Novelty: how little AlphaFold had to go on — 100 minus the highest sequence identity between this protein and any structure released before the 2018-04-30 training cutoff. High = genuinely unseen (100% = nothing similar was ever in the training set). novelty = 100 − maxₚ identity(s, p) over pre-cutoff PDB chains p, with identity = 100 × (matching aligned residues)/(alignment length), from an MMseqs2 search.

Homology: the point colour. High novelty (above 70%) flags the sequence as novel (amber) — AlphaFold had no close template; otherwise a pre-cutoff homolog existed (blue) it could have learned the fold from. novel ⇔ novelty > 70%.

What the metrics mean

TM-score (0–1): overall fold match — above 0.5 is the same fold, above 0.9 near-identical. Cα-RMSD (Å): average backbone distance after best-fit superposition — lower is better (under 2 Å is excellent). lDDT (0–1): local accuracy measured without superposition — above 0.8 is good. Each bar counts how many structures fall in that range.

Take-home: median TM-score 0.934 — most predictions match the experimental fold well, with a long tail that do not.

Read moreShow less — how each metric is calculated

TM-score: overall shape match, 0–1 (above 0.5 = same fold, above 0.9 near-identical), length-normalised. TM = (1/L) Σᵢ 1/(1 + (dᵢ/d₀)²) with dᵢ the aligned-Cα gap after superposition and d₀ = 1.24(L−15)^⅓ − 1.8. Ref: Zhang & Skolnick, Proteins 2004 doi:10.1002/prot.20264.

Cα-RMSD: the average straight-line distance between matching backbone Cα atoms once the two structures are best-fit superposed (Å; lower is better, under ~2 Å excellent). RMSD = √( (1/N) Σᵢ |Pᵢ − (R·Qᵢ + t)|² ), with Pᵢ/Qᵢ the experimental/model Cα coordinates and R,t the rotation and translation from Kabsch superposition.

lDDT: local accuracy with no superposition — the fraction of short-range inter-residue distances the model reproduces, so it is not fooled by a single wrongly-placed domain. lDDT = (1/N) Σᵢ ¼ Σ_t 1[ |d_exp − d_model| < t ] over thresholds t ∈ {0.5, 1, 2, 4} Å and all residue pairs within 15 Å.

Trend over time

The blue line is the mean TM-score of the structures by their deposit month; the red bars count how many were confidently wrong. Binning by deposit date (rather than by when we processed them) gives an even timeline, tracking whether AlphaFold's accuracy on newly-deposited structures is holding steady, improving, or slipping as the PDB keeps growing. Months with fewer than 5 structures are omitted so each point is a meaningful average. A dashed trend line is drawn only if the change over time is statistically significant.

Read moreShow less — how each metric is calculated

Mean TM-score: the month's average shape-match score. TM̄ = (1/M) Σ TM over the M structures deposited that month.

Trend line: a monotonic-trend test over the monthly means — Mann-Kendall (Kendall's τ) for significance, with a robust Theil-Sen slope for the line. Rank-based, so it tolerates the skewed TM distribution and noisy low-count months. Shown only when p < 0.05; otherwise a note reports that no significant trend was found.

Confidently wrong: the count that were both confident and wrong. count( mean pLDDT > 70 AND TM < 0.5 ).

Matched structures

PDB	UniProt	Protein	Method	Å	Deposited	Novelty %	pLDDT	TM	lDDT	GDT_TS	RMSD	FRAUD	Flag
8GFT_E	P53041	Serine/threonine-protein phosphatase 5	EM	3.80	2023-03-08	0.30	95.44	0.67	0.82	1.53	24.20	0.89	ok
8BYQ_7	P51948	CDK-activating kinase assembly factor MAT1	EM	4.10	2022-12-14	0.00	89.04	0.61	0.78	0.82	35.41	0.86	ok
8BVW_7	P51948	CDK-activating kinase assembly factor MAT1	EM	4.00	2022-12-20	0.00	89.69	0.60	0.73	2.24	31.52	0.84	ok
7VPX_E	Q7L014	Probable ATP-dependent RNA helicase DDX46	EM	3.00	2021-10-18	59.30	85.92	0.50	0.78	0.49	31.67	0.83	wrong
7ZNK_A	Q96FV9	THO complex subunit 1	EM	3.90	2022-04-21	0.00	89.47	0.59	0.82	1.83	33.05	0.83	ok
7ZNK_G	Q6I9Y2	THO complex subunit 7 homolog	EM	3.90	2022-04-21	100.00 novel	93.42	0.47	0.90	3.11	14.89	0.78	wrong
7VPX_G	P08579	U2 small nuclear ribonucleoprotein B''	EM	3.00	2021-10-18	0.00	93.11	0.56	0.85	5.27	16.08	0.77	ok
7VPX_C	Q12874	Splicing factor 3A subunit 3	EM	3.00	2021-10-18	73.80 novel	89.06	0.59	0.69	3.00	18.04	0.74	ok
7VPX_B	Q15428	Splicing factor 3A subunit 2	EM	3.00	2021-10-18	71.90 novel	90.61	0.55	0.73	4.76	14.68	0.73	ok
8GFT_C	Q16543	Hsp90 co-chaperone Cdc37, N-terminally pro	EM	3.80	2023-03-08	0.00	85.64	0.45	0.75	6.85	14.25	0.62	wrong
7VPX_D	Q15637	Splicing factor 1	EM	3.00	2021-10-18	0.70	90.14	0.61	0.89	10.04	11.57	0.60	ok
8ES9_G	P09693	T-cell surface glycoprotein CD3 gamma chai	EM	3.25	2022-10-13	0.00	84.39	0.64	0.84	9.27	12.59	0.59	ok
8ES8_G	P09693	T-cell surface glycoprotein CD3 gamma chai	EM	2.65	2022-10-13	0.00	84.39	0.64	0.85	9.27	12.61	0.59	ok
8ES7_G	P09693	T-cell surface glycoprotein CD3 gamma chai	EM	3.04	2022-10-13	0.00	84.39	0.64	0.86	8.62	12.56	0.58	ok
8EOJ_A	P07237	Protein disulfide-isomerase	EM	3.07	2022-10-03	0.30	93.59	0.61	0.77	15.35	10.48	0.54	ok
7VPX_4	Q15427	Splicing factor 3B subunit 4	EM	3.00	2021-10-18	3.20	94.55	0.55	0.77	16.25	10.59	0.54	ok
8BVW_R	P13984	General transcription factor IIF subunit 2	EM	4.00	2022-12-20	0.00	85.63	0.56	0.85	21.17	7.69	0.39	ok
8BYQ_R	P13984	General transcription factor IIF subunit 2	EM	4.10	2022-12-14	0.00	85.63	0.57	0.85	21.96	7.68	0.39	ok
8BZ1_R	P13984	General transcription factor IIF subunit 2	EM	3.80	2022-12-14	0.00	85.63	0.57	0.85	21.85	7.73	0.39	ok
8ES8_D	P04234	T-cell surface glycoprotein CD3 delta chai	EM	2.65	2022-10-13	0.00	89.74	0.66	0.91	35.38	5.25	0.28	ok
8FO6_B	P0DP23	Calmodulin-1	X-ray	2.55	2022-12-29	0.00	86.29	0.63	0.82	34.11	5.50	0.28	ok
7VPX_2	Q13435	Splicing factor 3B subunit 2	EM	3.00	2021-10-18	58.00	87.36	0.68	0.74	36.36	6.35	0.28	ok
8ES9_D	P04234	T-cell surface glycoprotein CD3 delta chai	EM	3.25	2022-10-13	0.00	89.74	0.66	0.91	35.61	5.16	0.28	ok
8ES7_D	P04234	T-cell surface glycoprotein CD3 delta chai	EM	3.04	2022-10-13	0.00	89.50	0.66	0.92	35.51	5.17	0.28	ok
7QRI_A	Q8IWU9	Tryptophan 5-hydroxylase 2	NMR	—	2022-01-11	—	83.12	0.72	—	—	—	0.24	ok
8ES8_P	P43358	Melanoma-associated antigen 4	EM	2.65	2022-10-13	—	90.90	0.35	0.69	37.50	4.27	0.23	wrong
8ES9_P	P43358	Melanoma-associated antigen 4	EM	3.25	2022-10-13	—	90.90	0.32	0.68	40.00	4.17	0.23	wrong
7XJJ_A	P09471	G protein subunit alpha o1,Guanine nucleot	EM	3.30	2022-04-18	—	94.50	0.77	—	—	—	0.22	ok
8DZQ_B	P09471	Guanine nucleotide-binding protein G(o) su	EM	2.82	2022-08-08	—	94.50	0.77	—	—	—	0.22	ok
7ZNK_E	Q13769	THO complex subunit 5 homolog	EM	3.90	2022-04-21	—	82.94	0.75	—	—	—	0.21	ok
7VPX_O	P08621	U1 small nuclear ribonucleoprotein 70 kDa	EM	3.00	2021-10-18	—	71.75	0.71	—	—	—	0.20	ok
8BYQ_3	Q92759	General transcription factor IIH subunit 4	EM	4.10	2022-12-14	—	85.25	0.76	—	—	—	0.20	ok
7VPX_1	O75533	Splicing factor 3B subunit 1	EM	3.00	2021-10-18	—	74.81	0.75	—	—	—	0.19	ok
8BVW_3	Q92759	General transcription factor IIH subunit 4	EM	4.00	2022-12-20	—	85.25	0.79	—	—	—	0.18	ok
8ES8_Y	P20963	T-cell surface glycoprotein CD3 zeta chain	EM	2.65	2022-10-13	—	62.41	0.72	—	—	—	0.18	ok
8DZS_B	P19086	Guanine nucleotide-binding protein G(z) su	EM	2.65	2022-08-08	—	93.56	0.82	—	—	—	0.17	ok
7XJJ_C	P22466	Galanin	EM	3.30	2022-04-18	100.00 novel	66.54	0.37	0.62	44.12	4.22	0.17	ok
8ES9_Y	P20963	T-cell surface glycoprotein CD3 zeta chain	EM	3.25	2022-10-13	—	62.41	0.74	—	—	—	0.16	ok
7XY6_G	P59768	Guanine nucleotide-binding protein G(I)/G(	EM	2.99	2022-05-31	—	89.56	0.82	—	—	—	0.16	ok
8DZP_B	P63096	Guanine nucleotide-binding protein G(i) su	EM	2.71	2022-08-08	—	93.75	0.83	—	—	—	0.16	ok
7XY7_G	P59768	Guanine nucleotide-binding protein G(I)/G(	EM	3.26	2022-05-31	—	89.56	0.82	—	—	—	0.16	ok
8BYQ_6	Q6ZYL4	General transcription factor IIH subunit 5	EM	4.10	2022-12-14	—	68.94	0.77	—	—	—	0.16	ok
8BVW_Q	P35269	General transcription factor IIF subunit 1	EM	4.00	2022-12-20	—	62.28	0.75	—	—	—	0.16	ok
7ZNK_L	Q86V81	THO complex subunit 4	EM	3.90	2022-04-21	—	64.12	0.76	—	—	—	0.16	ok
8SKK_B	Q92583	C-C motif chemokine 17	X-ray	2.10	2023-04-19	—	89.31	0.83	—	—	—	0.15	ok
8BZ1_Q	P35269	General transcription factor IIF subunit 1	EM	3.80	2022-12-14	—	62.28	0.75	—	—	—	0.15	ok
8BZ1_U	P52655	Transcription initiation factor IIA subuni	EM	3.80	2022-12-14	—	55.62	0.73	—	—	—	0.15	ok
8DY5_C	Q16552	Interleukin-17A	X-ray	2.20	2022-08-03	—	84.31	0.82	—	—	—	0.15	ok
8BYQ_Q	P35269	General transcription factor IIF subunit 1	EM	4.10	2022-12-14	—	62.28	0.76	—	—	—	0.15	ok
8BYQ_U	P52655	Transcription initiation factor IIA subuni	EM	4.10	2022-12-14	—	55.62	0.73	—	—	—	0.15	ok
8BVW_X	P29084	Transcription initiation factor IIE subuni	EM	4.00	2022-12-20	—	68.19	0.78	—	—	—	0.15	ok
8BVW_U	P52655	Transcription initiation factor IIA subuni	EM	4.00	2022-12-20	—	55.62	0.74	—	—	—	0.15	ok
8DY1_A	Q16552	Interleukin-17A	X-ray	2.68	2022-08-03	—	84.31	0.83	—	—	—	0.14	ok
8BYQ_X	P29084	Transcription initiation factor IIE subuni	EM	4.10	2022-12-14	—	68.19	0.79	—	—	—	0.14	ok
8BYQ_2	P32780	General transcription factor IIH subunit 1	EM	4.10	2022-12-14	—	73.88	0.81	—	—	—	0.14	ok
7XL6_A	Q96QZ0	Pannexin-3	EM	3.25	2022-04-21	—	81.75	0.83	—	—	—	0.14	ok
8BVW_6	Q6ZYL4	General transcription factor IIH subunit 5	EM	4.00	2022-12-20	0.00	69.73	0.68	0.77	53.62	4.00	0.13	ok
8ES8_E	P07766	T-cell surface glycoprotein CD3 epsilon ch	EM	2.65	2022-10-13	—	73.06	0.82	—	—	—	0.13	ok
8ES7_E	P07766	T-cell surface glycoprotein CD3 epsilon ch	EM	3.04	2022-10-13	—	73.06	0.82	—	—	—	0.13	ok
8ES9_E	P07766	T-cell surface glycoprotein CD3 epsilon ch	EM	3.25	2022-10-13	—	73.06	0.82	—	—	—	0.13	ok
7VPX_A	Q15459	Splicing factor 3A subunit 1	EM	3.00	2021-10-18	—	66.94	0.81	—	—	—	0.12	ok
8BVW_W	P29083	General transcription factor IIE subunit 1	EM	4.00	2022-12-20	—	66.69	0.82	—	—	—	0.12	ok
8DZS_D	P59768	Guanine nucleotide-binding protein G(I)/G(	EM	2.65	2022-08-08	—	89.56	0.87	—	—	—	0.12	ok
7XY7_A	P63092	Guanine nucleotide-binding protein G(s) su	EM	3.26	2022-05-31	—	91.31	0.87	—	—	—	0.12	ok
7XY6_A	P63092	Guanine nucleotide-binding protein G(s) su	EM	2.99	2022-05-31	—	91.31	0.87	—	—	—	0.12	ok
8BVW_2	P32780	General transcription factor IIH subunit 1	EM	4.00	2022-12-20	—	73.88	0.86	—	—	—	0.11	ok
7XUM_A	P35670	Copper-transporting ATPase 2	EM	3.80	2022-05-19	—	71.69	0.87	—	—	—	0.09	ok
8DZQ_A	P41145	Kappa-type opioid receptor	EM	2.82	2022-08-08	—	79.50	0.88	—	—	—	0.09	ok
8DZS_A	P41145	Kappa-type opioid receptor	EM	2.65	2022-08-08	—	79.50	0.89	—	—	—	0.09	ok
8GFT_D	P04049	RAF proto-oncogene serine/threonine-protei	EM	3.80	2023-03-08	—	67.50	0.87	—	—	—	0.09	ok
8DZP_A	P41145	Kappa-type opioid receptor	EM	2.71	2022-08-08	—	79.50	0.89	—	—	—	0.09	ok
7UZM_A	P00367	Glutamate dehydrogenase 1, mitochondrial	EM	3.24	2022-05-09	—	90.25	0.90	—	—	—	0.09	ok
7VPX_J	O75937	DnaJ homolog subfamily C member 8	EM	3.00	2021-10-18	—	83.75	0.90	—	—	—	0.09	ok
8FNY_B	P0DP23	Calmodulin-1	X-ray	2.22	2022-12-28	—	85.25	0.90	—	—	—	0.08	ok
8DZR_A	P41145	Kappa-type opioid receptor	EM	2.61	2022-08-08	—	79.50	0.89	—	—	—	0.08	ok
7VPX_N	P09234	U1 small nuclear ribonucleoprotein C	EM	3.00	2021-10-18	—	70.38	0.88	—	—	—	0.08	ok
8BYQ_W	P29083	General transcription factor IIE subunit 1	EM	4.10	2022-12-14	—	66.69	0.88	—	—	—	0.08	ok
8ES7_Y	P20963	T-cell surface glycoprotein CD3 zeta chain	EM	3.04	2022-10-13	0.00	85.01	0.68	0.94	78.23	1.80	0.08	ok
7VPX_5	Q9BWJ5	Splicing factor 3B subunit 5	EM	3.00	2021-10-18	—	91.62	0.92	—	—	—	0.08	ok
8DZQ_D	P59768	Guanine nucleotide-binding protein G(I)/G(	EM	2.82	2022-08-08	—	89.56	0.91	—	—	—	0.08	ok
8BYQ_8	P50613	Cyclin-dependent kinase 7	EM	4.10	2022-12-14	—	82.00	0.91	—	—	—	0.08	ok
8BVW_5	Q13889	General transcription factor IIH subunit 3	EM	4.00	2022-12-20	—	80.50	0.91	—	—	—	0.08	ok
8BZ1_M	Q00403	Transcription initiation factor IIB	EM	3.80	2022-12-14	—	87.25	0.91	—	—	—	0.08	ok
8BYQ_M	Q00403	Transcription initiation factor IIB	EM	4.10	2022-12-14	—	87.25	0.91	—	—	—	0.07	ok
7VPX_a	P62316	Small nuclear ribonucleoprotein Sm D2	EM	3.00	2021-10-18	—	90.62	0.92	—	—	—	0.07	ok
8BYQ_5	Q13889	General transcription factor IIH subunit 3	EM	4.10	2022-12-14	—	80.50	0.91	—	—	—	0.07	ok
8BVW_M	Q00403	Transcription initiation factor IIB	EM	4.00	2022-12-20	—	87.25	0.92	—	—	—	0.07	ok
7VPX_e	P62318	Small nuclear ribonucleoprotein Sm D3	EM	3.00	2021-10-18	—	82.81	0.91	—	—	—	0.07	ok
8BYQ_4	Q13888	General transcription factor IIH subunit 2	EM	4.10	2022-12-14	—	84.31	0.92	—	—	—	0.07	ok
8BVW_0	P19447	General transcription and DNA repair facto	EM	4.00	2022-12-20	—	75.94	0.91	—	—	—	0.07	ok
8BVW_4	Q13888	General transcription factor IIH subunit 2	EM	4.00	2022-12-20	—	84.31	0.92	—	—	—	0.07	ok
7XJJ_G	P59768	Guanine nucleotide-binding protein G(I)/G(	EM	3.30	2022-04-18	—	89.56	0.92	—	—	—	0.07	ok
8BVW_8	P50613	Cyclin-dependent kinase 7	EM	4.00	2022-12-20	—	82.00	0.92	—	—	—	0.07	ok
7XJJ_E	P47211	Galanin receptor type 1	EM	3.30	2022-04-18	—	83.81	0.92	—	—	—	0.07	ok
7VPX_d	P62308	Small nuclear ribonucleoprotein G	EM	3.00	2021-10-18	—	93.25	0.94	—	—	—	0.06	ok
7ZNK_H	Q13838	Spliceosome RNA helicase DDX39B	EM	3.90	2022-04-21	—	84.81	0.93	—	—	—	0.06	ok
8BVW_V	P52657	Transcription initiation factor IIA subuni	EM	4.00	2022-12-20	—	93.06	0.94	—	—	—	0.06	ok
7ZNK_B	Q8NI27	THO complex subunit 2	EM	3.90	2022-04-21	—	72.38	0.93	—	—	—	0.05	ok
7YIR_A	Q8WWN8	Arf-GAP with Rho-GAP domain, ANK repeat an	X-ray	2.10	2022-07-18	—	67.31	0.92	—	—	—	0.05	ok
8DZR_D	P59768	Guanine nucleotide-binding protein G(I)/G(	EM	2.61	2022-08-08	—	89.56	0.94	—	—	—	0.05	ok
8BYQ_0	P19447	General transcription and DNA repair facto	EM	4.10	2022-12-14	—	75.94	0.93	—	—	—	0.05	ok
8DZP_D	P59768	Guanine nucleotide-binding protein G(I)/G(	EM	2.71	2022-08-08	—	89.56	0.94	—	—	—	0.05	ok
8BZ1_V	P52657	Transcription initiation factor IIA subuni	EM	3.80	2022-12-14	—	93.06	0.95	—	—	—	0.05	ok
8BYQ_V	P52657	Transcription initiation factor IIA subuni	EM	4.10	2022-12-14	—	93.06	0.95	—	—	—	0.05	ok
8EOJ_B	P55157	Microsomal triglyceride transfer protein l	EM	3.07	2022-10-03	—	86.56	0.95	—	—	—	0.05	ok
7ZYP_A	P00533	Epidermal growth factor receptor	X-ray	2.80	2022-05-25	—	75.94	0.94	—	—	—	0.05	ok
7XF5_A	P51788	Chloride channel protein 2	EM	3.90	2022-04-01	—	72.75	0.94	—	—	—	0.04	ok
8BSC_A	Q06609	DNA repair protein RAD51 homolog 1	EM	3.60	2022-11-24	—	91.44	0.95	—	—	—	0.04	ok
7VPX_f	P14678	Small nuclear ribonucleoprotein-associated	EM	3.00	2021-10-18	—	69.50	0.94	—	—	—	0.04	ok
8FNY_A	O00418	Eukaryotic elongation factor 2 kinase	X-ray	2.22	2022-12-28	—	71.81	0.94	—	—	—	0.04	ok
8EKW_A	Q13162	Peroxiredoxin-4	EM	2.83	2022-09-22	—	84.31	0.95	—	—	—	0.04	ok
7ZYM_A	P00533	Epidermal growth factor receptor	X-ray	2.50	2022-05-25	—	75.94	0.95	—	—	—	0.04	ok
7ZYN_A	P00533	Epidermal growth factor receptor	X-ray	2.30	2022-05-25	—	75.94	0.95	—	—	—	0.04	ok
8GFT_A	P08238	Heat shock protein HSP 90-beta	EM	3.80	2023-03-08	—	84.31	0.95	—	—	—	0.04	ok
8FO6_A	O00418	Eukaryotic elongation factor 2 kinase	X-ray	2.55	2022-12-29	—	71.81	0.95	—	—	—	0.04	ok
7VPX_b	P62306	Small nuclear ribonucleoprotein F	EM	3.00	2021-10-18	—	90.50	0.96	—	—	—	0.04	ok
8EKY_M	Q8NBS9	Thioredoxin domain-containing protein 5	EM	3.47	2022-09-22	—	80.62	0.96	—	—	—	0.04	ok
7ZYQ_A	P00533	Epidermal growth factor receptor	X-ray	2.10	2022-05-25	—	75.94	0.96	—	—	—	0.03	ok
7VPX_c	P62304	Small nuclear ribonucleoprotein E	EM	3.00	2021-10-18	—	90.75	0.96	—	—	—	0.03	ok
7VPX_g	P62314	Small nuclear ribonucleoprotein Sm D1	EM	3.00	2021-10-18	—	82.81	0.96	—	—	—	0.03	ok
8D6J_A	Q9UKV8	Protein argonaute-2	X-ray	2.50	2022-06-06	—	92.38	0.97	—	—	—	0.03	ok
7ZNK_F	Q86W42	THO complex subunit 6 homolog	EM	3.90	2022-04-21	—	93.62	0.97	—	—	—	0.03	ok
8B3K_A	O43157	Plexin-B1	X-ray	2.69	2022-09-16	—	75.19	0.96	—	—	—	0.03	ok
7YUN_A	Q5SZJ8	BEN domain-containing protein 6	X-ray	2.13	2022-08-17	—	71.81	0.96	—	—	—	0.03	ok
8D71_A	Q9UKV8	Protein argonaute-2	X-ray	2.50	2022-06-07	—	92.38	0.97	—	—	—	0.03	ok
7TYU_A	Q15562	Transcriptional enhancer factor TEF-4	X-ray	1.78	2022-02-14	—	70.75	0.96	—	—	—	0.03	ok
8EKY_A	Q13162	Peroxiredoxin-4	EM	3.47	2022-09-22	—	84.31	0.97	—	—	—	0.03	ok
7XMP_A	P78380	Oxidized low-density lipoprotein receptor	X-ray	1.27	2022-04-26	—	87.44	0.97	—	—	—	0.03	ok
8G0L_B	Q14CX7	N-alpha-acetyltransferase 25, NatB auxilia	EM	3.39	2023-01-31	—	91.12	0.97	—	—	—	0.03	ok
7YIS_A	Q8WWN8	Arf-GAP with Rho-GAP domain, ANK repeat an	X-ray	3.30	2022-07-18	—	67.31	0.96	—	—	—	0.03	ok
7TYP_A	Q15562	Transcriptional enhancer factor TEF-4	X-ray	1.60	2022-02-14	—	70.75	0.96	—	—	—	0.03	ok
8BVW_1	P18074	TFIIH basal transcription factor complex h	EM	4.00	2022-12-20	—	87.56	0.97	—	—	—	0.03	ok
8EA5_A	P26718	NKG2-D type II integral membrane protein	X-ray	1.63	2022-08-28	—	79.19	0.97	—	—	—	0.03	ok
7VPX_6	Q7RTV0	PHD finger-like domain-containing protein	EM	3.00	2021-10-18	—	89.88	0.97	—	—	—	0.03	ok
8BYQ_1	P18074	TFIIH basal transcription factor complex h	EM	4.10	2022-12-14	—	87.56	0.97	—	—	—	0.02	ok
8G0L_A	P61599	N-alpha-acetyltransferase 20	EM	3.39	2023-01-31	—	94.00	0.98	—	—	—	0.02	ok
7TYQ_A	Q15562	Transcriptional enhancer factor TEF-4	X-ray	1.88	2022-02-14	—	70.75	0.97	—	—	—	0.02	ok
8ES9_M	P61769	Beta-2-microglobulin	EM	3.25	2022-10-13	—	94.06	0.98	—	—	—	0.02	ok
8EA9_A	P26718	NKG2-D type II integral membrane protein	X-ray	1.58	2022-08-28	—	79.19	0.98	—	—	—	0.02	ok
8EA8_A	P26718	NKG2-D type II integral membrane protein	X-ray	1.77	2022-08-28	—	79.19	0.98	—	—	—	0.02	ok
8ES9_N	Q861F7	MHC class I antigen	EM	3.25	2022-10-13	—	88.19	0.98	—	—	—	0.02	ok
8EM2_A	O95479	GDH/6PGL endoplasmic bifunctional protein	EM	3.02	2022-09-26	—	90.56	0.98	—	—	—	0.02	ok
8H6D_A	Q92830	Histone acetyltransferase KAT2A	X-ray	3.26	2022-10-16	—	77.69	0.98	—	—	—	0.02	ok
8BYQ_9	P51946	Cyclin-H	EM	4.10	2022-12-14	—	86.38	0.98	—	—	—	0.02	ok
8ES8_N	Q861F7	MHC class I antigen	EM	2.65	2022-10-13	—	88.19	0.98	—	—	—	0.02	ok
8ES8_M	P61769	Beta-2-microglobulin	EM	2.65	2022-10-13	—	94.06	0.98	—	—	—	0.02	ok
8H65_A	Q92830	Histone acetyltransferase KAT2A	X-ray	3.00	2022-10-15	—	77.69	0.98	—	—	—	0.02	ok
8EAA_A	P26718	NKG2-D type II integral membrane protein	X-ray	1.57	2022-08-28	—	79.19	0.98	—	—	—	0.02	ok
8AVA_A	P09960	Leukotriene A-4 hydrolase	X-ray	1.35	2022-08-26	—	96.25	0.98	—	—	—	0.02	ok
8BVW_9	P51946	Cyclin-H	EM	4.00	2022-12-20	—	86.38	0.98	—	—	—	0.02	ok
8H66_A	Q92830	Histone acetyltransferase KAT2A	X-ray	2.80	2022-10-15	—	77.69	0.98	—	—	—	0.02	ok
7X1B_B	P61769	Beta-2-microglobulin	X-ray	1.40	2022-02-23	—	94.06	0.98	—	—	—	0.02	ok
8AWH_A	P09960	Leukotriene A-4 hydrolase	X-ray	1.42	2022-08-29	—	96.25	0.98	—	—	—	0.02	ok
8HJE_A	Q96RU2	Ubiquitin carboxyl-terminal hydrolase 28	X-ray	2.85	2022-11-23	—	73.06	0.98	—	—	—	0.02	ok
7WZZ_B	P61769	Beta-2-microglobulin	X-ray	1.30	2022-02-20	—	94.06	0.98	—	—	—	0.02	ok
8HY4_A	P02766	Transthyretin	X-ray	1.53	2023-01-05	—	88.00	0.98	—	—	—	0.01	ok
8H6C_A	Q92830	Histone acetyltransferase KAT2A	X-ray	2.50	2022-10-16	—	77.69	0.98	—	—	—	0.01	ok
7XY7_B	P62873	Guanine nucleotide-binding protein G(I)/G(	EM	3.26	2022-05-31	—	97.06	0.99	—	—	—	0.01	ok
8EA7_A	P26718	NKG2-D type II integral membrane protein	X-ray	1.28	2022-08-28	—	79.19	0.98	—	—	—	0.01	ok
8ESB_A	Q53Z42	Beta-2-microglobulin,HLA class I antigen,M	EM	3.12	2022-10-13	—	85.25	0.98	—	—	—	0.01	ok
7UU0_A	P25440	Isoform 3 of Bromodomain-containing protei	X-ray	1.30	2022-04-28	—	64.06	0.98	—	—	—	0.01	ok
8EAB_A	P26718	NKG2-D type II integral membrane protein	X-ray	1.44	2022-08-28	—	79.19	0.98	—	—	—	0.01	ok
7X1C_B	P61769	Beta-2-microglobulin	X-ray	1.41	2022-02-23	—	94.06	0.99	—	—	—	0.01	ok
7YCQ_A	P02766	Transthyretin	X-ray	1.99	2022-07-01	—	88.00	0.98	—	—	—	0.01	ok
7XY6_B	P62873	Guanine nucleotide-binding protein G(I)/G(	EM	2.99	2022-05-31	—	97.06	0.99	—	—	—	0.01	ok
8BQ2_A	Q06609	DNA repair protein RAD51 homolog 1	EM	3.80	2022-11-18	—	91.44	0.99	—	—	—	0.01	ok
7X00_B	P61769	Beta-2-microglobulin	X-ray	1.45	2022-02-20	—	94.06	0.99	—	—	—	0.01	ok
8BVW_O	P20226	TATA-box-binding protein	EM	4.00	2022-12-20	—	77.12	0.98	—	—	—	0.01	ok
7VPX_3	Q15393	Splicing factor 3B subunit 3	EM	3.00	2021-10-18	—	92.25	0.99	—	—	—	0.01	ok
8BZ1_O	P20226	TATA-box-binding protein	EM	3.80	2022-12-14	—	77.12	0.99	—	—	—	0.01	ok
7ZNK_C	Q96J01	THO complex subunit 3	EM	3.90	2022-04-21	—	90.19	0.99	—	—	—	0.01	ok
8G44_A	Q9UBN7	Histone deacetylase 6	X-ray	1.55	2023-02-08	—	76.75	0.99	—	—	—	0.01	ok
7Y6J_A	P02766	Transthyretin	X-ray	1.38	2022-06-20	—	88.00	0.99	—	—	—	0.01	ok
7YBR_A	P02766	Transthyretin	X-ray	1.71	2022-06-29	—	88.00	0.99	—	—	—	0.01	ok
8DZQ_C	P62873	Guanine nucleotide-binding protein G(I)/G(	EM	2.82	2022-08-08	—	97.06	0.99	—	—	—	0.01	ok
8BYQ_O	P20226	TATA-box-binding protein	EM	4.10	2022-12-14	—	77.12	0.99	—	—	—	0.01	ok
8EA6_A	P26718	NKG2-D type II integral membrane protein	X-ray	1.73	2022-08-28	—	79.19	0.99	—	—	—	0.01	ok
8G45_A	Q9UBN7	Histone deacetylase 6	X-ray	1.62	2023-02-08	—	76.75	0.99	—	—	—	0.01	ok
7VPX_M	P09012	U1 small nuclear ribonucleoprotein A	EM	3.00	2021-10-18	—	79.50	0.99	—	—	—	0.01	ok
8G43_A	Q9UBN7	Histone deacetylase 6	X-ray	1.55	2023-02-08	—	76.75	0.99	—	—	—	0.01	ok
7XJJ_B	P62873	Guanine nucleotide-binding protein G(I)/G(	EM	3.30	2022-04-18	—	97.06	0.99	—	—	—	0.01	ok
7VPX_F	P09661	U2 small nuclear ribonucleoprotein A'	EM	3.00	2021-10-18	—	87.69	0.99	—	—	—	0.01	ok
8DZS_C	P62873	Guanine nucleotide-binding protein G(I)/G(	EM	2.65	2022-08-08	—	97.06	0.99	—	—	—	0.01	ok
8DZR_C	P62873	Guanine nucleotide-binding protein G(I)/G(	EM	2.61	2022-08-08	—	97.06	1.00	—	—	—	0.00	ok
7XOT_A	Q14145	Kelch-like ECH-associated protein 1	X-ray	2.70	2022-05-01	—	90.06	1.00	—	—	—	0.00	ok
8ENE_A	P00352	Retinal dehydrogenase 1	EM	2.64	2022-09-29	—	97.81	1.00	—	—	—	0.00	ok
7X1B_A	A0A678ZMW1	HLA-B	X-ray	1.40	2022-02-23	—	86.31	1.00	—	—	—	0.00	ok
8BR2_A	Q06609	DNA repair protein RAD51 homolog 1	EM	2.90	2022-11-22	—	91.44	1.00	—	—	—	0.00	ok
7WZZ_A	F4NC28	MHC class I antigen	X-ray	1.30	2022-02-20	—	89.81	1.00	—	—	—	0.00	ok
8DZP_C	P62873	Guanine nucleotide-binding protein G(I)/G(	EM	2.71	2022-08-08	—	97.06	1.00	—	—	—	0.00	ok
7X00_A	F4NC28	MHC class I antigen	X-ray	1.45	2022-02-20	—	89.81	1.00	—	—	—	0.00	ok
8FOG_A	Q9Y253	DNA polymerase eta	X-ray	2.29	2022-12-30	—	76.88	1.00	—	—	—	0.00	ok
7X1C_A	A0A678ZMW1	HLA-B	X-ray	1.41	2022-02-23	—	86.31	1.00	—	—	—	0.00	ok
8FN3_A	Q9Y253	DNA polymerase eta	X-ray	2.17	2022-12-26	—	76.88	1.00	—	—	—	0.00	ok
8EOR_A	P23141	Liver carboxylesterase 1	EM	2.67	2022-10-04	—	93.31	1.00	—	—	—	0.00	ok

Click a column header to sort. FRAUD = confidence-weighted error; a structure is flagged confidently wrong when mean pLDDT > 70 yet TM-score < 0.5.