Release week 2021-03-10
⭐ This week's notable releases
18 novel sequences, 7 confidently wrong. Highlight: Fanconi anemia group B protein.
| PDB | Protein | Flags | Why it matters |
|---|---|---|---|
|
|
Fanconi anemia group B protein | novel · 100% confidently wrong | Genuinely unseen sequence (0% identity to anything AlphaFold trained on) — and AlphaFold got the fold wrong despite high confidence. |
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|
Fanconi anemia group B protein | novel · 100% confidently wrong | Genuinely unseen sequence (0% identity to anything AlphaFold trained on) — and AlphaFold got the fold wrong despite high confidence. |
|
|
Fanconi anemia group B protein | novel · 100% confidently wrong | Genuinely unseen sequence (0% identity to anything AlphaFold trained on) — and AlphaFold got the fold wrong despite high confidence. |
|
|
Fanconi anemia group B protein | novel · 100% confidently wrong | Genuinely unseen sequence (0% identity to anything AlphaFold trained on) — and AlphaFold got the fold wrong despite high confidence. |
|
|
Fanconi anemia group B protein | novel · 100% confidently wrong | Genuinely unseen sequence (0% identity to anything AlphaFold trained on) — and AlphaFold got the fold wrong despite high confidence. |
|
|
Fanconi anemia group B protein | novel · 100% confidently wrong | Genuinely unseen sequence (0% identity to anything AlphaFold trained on) — and AlphaFold got the fold wrong despite high confidence. |
Zoomed into the red "confidently wrong" box above (pLDDT ≥ 70, TM < 0.5) — the structures AlphaFold got confidently wrong.
The worst offenders ranked, one row per protein (AlphaFold has one model per sequence, so repeat depositions are collapsed — “×N” marks how many structures of that protein exist; the worst is shown). Each row joins what AlphaFold claimed (blue, pLDDT/100) to what the experiment showed (red, TM-score) — the longer the bar, the bigger the miss. Hover a dot to preview its Cα-deviation ribbon; click to open the full entry.
How to read this
Every point is one experimental protein structure. The horizontal axis is AlphaFold's own confidence in its prediction (mean pLDDT, 0–100). The vertical axis is how well that blind prediction actually matches the experiment (TM-score, 0–1; above 0.5 means the same fold, above 0.9 near-identical). Marker size grows with the FRAUD score (confidence-weighted error).
Cutoff: the shaded red box is the "confidently wrong" zone — AlphaFold was confident (mean pLDDT above 70) yet the fold is wrong (TM-score below 0.5). A predictor that had truly solved folding would leave that box empty.
Take-home: 7 of 152 structures (4.6%) are confidently wrong; median TM-score is 0.901.
Read moreShow less — how each metric is calculated
TM-score: how similar the two 3D shapes are overall, 0–1 (a random pair scores ~0.17, an identical fold ~1). Length-normalised so large and small proteins compare fairly. TM = (1/L) Σᵢ 1/(1 + (dᵢ/d₀)²) — dᵢ is the gap between the i-th aligned Cα atoms after best-fit superposition, and d₀ = 1.24(L−15)^⅓ − 1.8 sets the distance scale for length L. Ref: Zhang & Skolnick, Proteins 2004 doi:10.1002/prot.20264; computed with TM-align, doi:10.1093/nar/gki524.
pLDDT: AlphaFold's own confidence in each residue, 0–100 (higher = surer). It is the model predicting its own accuracy before ever seeing the experiment. We plot the per-structure mean. pLDDT = (1/N) Σᵢ pLDDTᵢ, where pLDDTᵢ is the network's confidence output for residue i.
FRAUD score: the headline number — how wrong the prediction was, weighted by how confident AlphaFold was, so a big error it was sure about counts most. FRAUD = (1/N) Σᵢ (pLDDTᵢ/100) · min(Δᵢ,15)/15, where Δᵢ is residue i's Cα distance from the experiment (Å) after superposition, capped at 15 Å. Runs 0 (perfect) to 1.
Novelty: how little AlphaFold had to go on — 100 minus the highest sequence identity between this protein and any structure released before the 2018-04-30 training cutoff. High = genuinely unseen (100% = nothing similar was ever in the training set). novelty = 100 − maxₚ identity(s, p) over pre-cutoff PDB chains p, with identity = 100 × (matching aligned residues)/(alignment length), from an MMseqs2 search.
Homology: the point colour. High novelty (above 70%) flags the sequence as novel (amber) — AlphaFold had no close template; otherwise a pre-cutoff homolog existed (blue) it could have learned the fold from. novel ⇔ novelty > 70%.
What the metrics mean
TM-score (0–1): overall fold match — above 0.5 is the same fold, above 0.9 near-identical. Cα-RMSD (Å): average backbone distance after best-fit superposition — lower is better (under 2 Å is excellent). lDDT (0–1): local accuracy measured without superposition — above 0.8 is good. Each bar counts how many structures fall in that range.
Take-home: median TM-score 0.901 — most predictions match the experimental fold well, with a long tail that do not.
Read moreShow less — how each metric is calculated
TM-score: overall shape match, 0–1 (above 0.5 = same fold, above 0.9 near-identical), length-normalised. TM = (1/L) Σᵢ 1/(1 + (dᵢ/d₀)²) with dᵢ the aligned-Cα gap after superposition and d₀ = 1.24(L−15)^⅓ − 1.8. Ref: Zhang & Skolnick, Proteins 2004 doi:10.1002/prot.20264.
Cα-RMSD: the average straight-line distance between matching backbone Cα atoms once the two structures are best-fit superposed (Å; lower is better, under ~2 Å excellent). RMSD = √( (1/N) Σᵢ |Pᵢ − (R·Qᵢ + t)|² ), with Pᵢ/Qᵢ the experimental/model Cα coordinates and R,t the rotation and translation from Kabsch superposition.
lDDT: local accuracy with no superposition — the fraction of short-range inter-residue distances the model reproduces, so it is not fooled by a single wrongly-placed domain. lDDT = (1/N) Σᵢ ¼ Σ_t 1[ |d_exp − d_model| < t ] over thresholds t ∈ {0.5, 1, 2, 4} Å and all residue pairs within 15 Å.
Trend over time
The blue line is the mean TM-score of the structures by their deposit month; the red bars count how many were confidently wrong. Binning by deposit date (rather than by when we processed them) gives an even timeline, tracking whether AlphaFold's accuracy on newly-deposited structures is holding steady, improving, or slipping as the PDB keeps growing. Months with fewer than 5 structures are omitted so each point is a meaningful average. A dashed trend line is drawn only if the change over time is statistically significant.
Read moreShow less — how each metric is calculated
Mean TM-score: the month's average shape-match score. TM̄ = (1/M) Σ TM over the M structures deposited that month.
Trend line: a monotonic-trend test over the monthly means — Mann-Kendall (Kendall's τ) for significance, with a robust Theil-Sen slope for the line. Rank-based, so it tolerates the skewed TM distribution and noisy low-count months. Shown only when p < 0.05; otherwise a note reports that no significant trend was found.
Confidently wrong: the count that were both confident and wrong. count( mean pLDDT > 70 AND TM < 0.5 ).
Matched structures
| PDB | UniProt | Protein | Method | Å | Deposited | Novelty % | pLDDT | TM | lDDT | GDT_TS | RMSD | FRAUD | Flag |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 7KZS_E | Q9HB96 | Fanconi anemia group E protein | EM | 4.20 | 2020-12-10 | 0.40 | 86.70 | 0.58 | 0.85 | 0.18 | 52.72 | 0.86 | ok |
| 7KZR_E | Q9HB96 | Fanconi anemia group E protein | EM | 4.40 | 2020-12-10 | 0.40 | 86.70 | 0.57 | 0.85 | 0.18 | 53.09 | 0.86 | ok |
| 7KZQ_E | Q9HB96 | Fanconi anemia group E protein | EM | 4.30 | 2020-12-10 | 0.40 | 86.70 | 0.57 | 0.87 | 0.24 | 52.83 | 0.86 | ok |
| 7KZT_E | Q9HB96 | Fanconi anemia group E protein | EM | 4.20 | 2020-12-10 | 0.40 | 86.70 | 0.58 | 0.85 | 0.18 | 52.74 | 0.86 | ok |
| 7KZV_E | Q9HB96 | Fanconi anemia group E protein | EM | 4.20 | 2020-12-10 | 0.40 | 86.70 | 0.56 | 0.85 | 0.24 | 53.00 | 0.86 | ok |
| 7KZS_A | O15360 | Fanconi anemia group A protein | EM | 4.20 | 2020-12-10 | 100.00 novel | 78.51 | 0.60 | 0.80 | 1.08 | 35.08 | 0.75 | ok |
| 7KZT_A | O15360 | Fanconi anemia group A protein | EM | 4.20 | 2020-12-10 | 100.00 novel | 78.51 | 0.60 | 0.79 | 1.08 | 35.06 | 0.75 | ok |
| 7KZP_A | O15360 | Fanconi anemia group A protein | EM | 3.10 | 2020-12-10 | 100.00 novel | 78.51 | 0.60 | 0.79 | 1.14 | 34.31 | 0.75 | ok |
| 7KZV_A | O15360 | Fanconi anemia group A protein | EM | 4.20 | 2020-12-10 | 100.00 novel | 78.51 | 0.60 | 0.79 | 1.12 | 35.07 | 0.75 | ok |
| 7KZQ_A | O15360 | Fanconi anemia group A protein | EM | 4.30 | 2020-12-10 | 100.00 novel | 78.51 | 0.60 | 0.79 | 1.10 | 34.78 | 0.75 | ok |
| 7KZR_A | O15360 | Fanconi anemia group A protein | EM | 4.40 | 2020-12-10 | 100.00 novel | 78.51 | 0.61 | 0.78 | 1.18 | 34.53 | 0.75 | ok |
| 7KZV_B | Q8NB91 | Fanconi anemia group B protein | EM | 4.20 | 2020-12-10 | 100.00 novel | 78.02 | 0.47 | 0.81 | 1.18 | 31.78 | 0.74 | wrong |
| 7KZT_B | Q8NB91 | Fanconi anemia group B protein | EM | 4.20 | 2020-12-10 | 100.00 novel | 78.02 | 0.47 | 0.81 | 1.21 | 31.73 | 0.74 | wrong |
| 7KZS_B | Q8NB91 | Fanconi anemia group B protein | EM | 4.20 | 2020-12-10 | 100.00 novel | 78.02 | 0.47 | 0.81 | 1.18 | 31.73 | 0.74 | wrong |
| 7KZP_B | Q8NB91 | Fanconi anemia group B protein | EM | 3.10 | 2020-12-10 | 100.00 novel | 78.02 | 0.47 | 0.82 | 1.21 | 31.65 | 0.74 | wrong |
| 7KZQ_B | Q8NB91 | Fanconi anemia group B protein | EM | 4.30 | 2020-12-10 | 100.00 novel | 78.02 | 0.47 | 0.81 | 1.21 | 31.81 | 0.74 | wrong |
| 7KZR_B | Q8NB91 | Fanconi anemia group B protein | EM | 4.40 | 2020-12-10 | 100.00 novel | 78.02 | 0.47 | 0.79 | 1.28 | 31.84 | 0.74 | wrong |
| 7LBF_D | P16234 | Isoform 3 of Platelet-derived growth facto | EM | 2.80 | 2021-01-07 | 68.30 | 82.72 | 0.63 | 0.87 | 6.84 | 13.90 | 0.62 | ok |
| 7KZR_L | Q9NW38 | E3 ubiquitin-protein ligase FANCL | EM | 4.40 | 2020-12-10 | 0.00 | 91.94 | 0.58 | 0.85 | 10.74 | 13.64 | 0.60 | ok |
| 7KZT_L | Q9NW38 | E3 ubiquitin-protein ligase FANCL | EM | 4.20 | 2020-12-10 | 0.00 | 91.94 | 0.58 | 0.86 | 11.15 | 13.64 | 0.59 | ok |
| 7KZS_L | Q9NW38 | E3 ubiquitin-protein ligase FANCL | EM | 4.20 | 2020-12-10 | 0.00 | 91.94 | 0.58 | 0.87 | 10.95 | 13.63 | 0.59 | ok |
| 7KZV_L | Q9NW38 | E3 ubiquitin-protein ligase FANCL | EM | 4.20 | 2020-12-10 | 0.00 | 91.94 | 0.58 | 0.87 | 11.22 | 13.60 | 0.59 | ok |
| 7KZQ_L | Q9NW38 | E3 ubiquitin-protein ligase FANCL | EM | 4.30 | 2020-12-10 | 0.00 | 91.94 | 0.58 | 0.88 | 11.01 | 13.56 | 0.59 | ok |
| 7KZP_L | Q9NW38 | E3 ubiquitin-protein ligase FANCL | EM | 3.10 | 2020-12-10 | 0.00 | 91.94 | 0.58 | 0.88 | 11.28 | 13.52 | 0.59 | ok |
| 7DM4_A | Q4LE39 | AT-rich interactive domain-containing prot | NMR | — | 2020-12-02 | 19.70 | 77.35 | 0.43 | 0.71 | 6.46 | 15.57 | 0.56 | wrong |
| 7KZS_P | Q0VG06 | Fanconi anemia core complex-associated pro | EM | 4.20 | 2020-12-10 | 100.00 novel | 79.81 | 0.60 | 0.79 | 14.37 | 15.50 | 0.52 | ok |
| 7KZT_P | Q0VG06 | Fanconi anemia core complex-associated pro | EM | 4.20 | 2020-12-10 | 100.00 novel | 79.81 | 0.60 | 0.78 | 14.54 | 15.41 | 0.52 | ok |
| 7KZP_P | Q0VG06 | Fanconi anemia core complex-associated pro | EM | 3.10 | 2020-12-10 | 100.00 novel | 79.81 | 0.60 | 0.80 | 14.94 | 15.39 | 0.52 | ok |
| 7KZV_P | Q0VG06 | Fanconi anemia core complex-associated pro | EM | 4.20 | 2020-12-10 | 100.00 novel | 79.81 | 0.60 | 0.78 | 15.04 | 15.43 | 0.52 | ok |
| 7KZQ_P | Q0VG06 | Fanconi anemia core complex-associated pro | EM | 4.30 | 2020-12-10 | 100.00 novel | 79.81 | 0.60 | 0.79 | 15.11 | 15.42 | 0.52 | ok |
| 7KZR_P | Q0VG06 | Fanconi anemia core complex-associated pro | EM | 4.40 | 2020-12-10 | 100.00 novel | 79.81 | 0.60 | 0.77 | 14.71 | 15.38 | 0.51 | ok |
| 7KZR_F | Q9NPI8 | Fanconi anemia group F protein | EM | 4.40 | 2020-12-10 | 0.00 | 82.27 | 0.66 | 0.81 | 32.72 | 5.89 | 0.27 | ok |
| 7KZS_F | Q9NPI8 | Fanconi anemia group F protein | EM | 4.20 | 2020-12-10 | 0.00 | 82.27 | 0.67 | 0.81 | 33.01 | 5.87 | 0.27 | ok |
| 7KZV_F | Q9NPI8 | Fanconi anemia group F protein | EM | 4.20 | 2020-12-10 | 0.00 | 82.27 | 0.66 | 0.81 | 33.90 | 5.87 | 0.27 | ok |
| 7KZT_F | Q9NPI8 | Fanconi anemia group F protein | EM | 4.20 | 2020-12-10 | 0.00 | 82.27 | 0.67 | 0.82 | 33.53 | 5.87 | 0.27 | ok |
| 7KZP_F | Q9NPI8 | Fanconi anemia group F protein | EM | 3.10 | 2020-12-10 | 0.00 | 82.27 | 0.67 | 0.83 | 33.53 | 5.87 | 0.27 | ok |
| 7KZQ_F | Q9NPI8 | Fanconi anemia group F protein | EM | 4.30 | 2020-12-10 | 0.00 | 82.27 | 0.67 | 0.83 | 33.90 | 5.82 | 0.27 | ok |
| 7NMU_AAA | Q9HCN6 | Platelet glycoprotein VI | X-ray | 2.50 | 2021-02-23 | — | 76.06 | 0.71 | — | — | — | 0.22 | ok |
| 7K36_A | P30153 | Serine/threonine-protein phosphatase 2A 65 | EM | 3.30 | 2020-09-10 | — | 94.94 | 0.77 | — | — | — | 0.22 | ok |
| 7KZV_V | Q9BXW9 | Fanconi anemia group D2 protein | EM | 4.20 | 2020-12-10 | — | 76.75 | 0.76 | — | — | — | 0.19 | ok |
| 7KZP_E | Q9HB96 | Fanconi anemia group E protein | EM | 3.10 | 2020-12-10 | — | 76.00 | 0.77 | — | — | — | 0.18 | ok |
| 7KZS_V | Q9BXW9 | Fanconi anemia group D2 protein | EM | 4.20 | 2020-12-10 | — | 76.75 | 0.77 | — | — | — | 0.17 | ok |
| 7CMU_A | P63096 | Guanine nucleotide-binding protein G(i) su | EM | 3.00 | 2020-07-29 | — | 93.75 | 0.82 | — | — | — | 0.17 | ok |
| 7CMV_A | P63096 | Guanine nucleotide-binding protein G(i) su | EM | 2.70 | 2020-07-29 | — | 93.75 | 0.82 | — | — | — | 0.16 | ok |
| 7KZT_V | Q9BXW9 | Fanconi anemia group D2 protein | EM | 4.20 | 2020-12-10 | — | 76.75 | 0.80 | — | — | — | 0.15 | ok |
| 7LWB_D | Q969X0 | RILP-like protein 2 | X-ray | 1.90 | 2021-02-28 | — | 77.19 | 0.81 | — | — | — | 0.15 | ok |
| 7DTV_A | P41180 | Extracellular calcium-sensing receptor | EM | 3.50 | 2021-01-06 | — | 75.69 | 0.82 | — | — | — | 0.14 | ok |
| 7DTT_A | P41180 | Extracellular calcium-sensing receptor | EM | 3.80 | 2021-01-06 | — | 75.69 | 0.82 | — | — | — | 0.14 | ok |
| 7KZQ_V | Q9BXW9 | Fanconi anemia group D2 protein | EM | 4.30 | 2020-12-10 | — | 76.75 | 0.82 | — | — | — | 0.13 | ok |
| 7KZR_V | Q9BXW9 | Fanconi anemia group D2 protein | EM | 4.40 | 2020-12-10 | — | 76.75 | 0.83 | — | — | — | 0.13 | ok |
| 6W2G_A | P54725 | UV excision repair protein RAD23 homolog A | X-ray | 1.10 | 2020-03-05 | — | 69.38 | 0.82 | — | — | — | 0.13 | ok |
| 6W2I_A | P54725 | UV excision repair protein RAD23 homolog A | X-ray | 1.45 | 2020-03-05 | — | 69.38 | 0.82 | — | — | — | 0.13 | ok |
| 7JXU_A | Q8NB16 | Mixed lineage kinase domain-like protein | X-ray | 2.44 | 2020-08-28 | — | 83.12 | 0.85 | — | — | — | 0.12 | ok |
| 6W2H_A | P54725 | UV excision repair protein RAD23 homolog A | X-ray | 1.60 | 2020-03-05 | — | 69.38 | 0.83 | — | — | — | 0.12 | ok |
| 6X6A_C | Q9C000 | NACHT, LRR and PYD domains-containing prot | EM | 3.60 | 2020-05-27 | — | 68.25 | 0.83 | — | — | — | 0.12 | ok |
| 7KZP_G | O15287 | Fanconi anemia group G protein | EM | 3.10 | 2020-12-10 | — | 83.12 | 0.87 | — | — | — | 0.11 | ok |
| 7KZS_G | O15287 | Fanconi anemia group G protein | EM | 4.20 | 2020-12-10 | — | 83.12 | 0.87 | — | — | — | 0.11 | ok |
| 7KZT_G | O15287 | Fanconi anemia group G protein | EM | 4.20 | 2020-12-10 | — | 83.12 | 0.87 | — | — | — | 0.11 | ok |
| 7KZR_G | O15287 | Fanconi anemia group G protein | EM | 4.40 | 2020-12-10 | — | 83.12 | 0.87 | — | — | — | 0.11 | ok |
| 7KZV_G | O15287 | Fanconi anemia group G protein | EM | 4.20 | 2020-12-10 | — | 83.12 | 0.87 | — | — | — | 0.11 | ok |
| 7KZQ_G | O15287 | Fanconi anemia group G protein | EM | 4.30 | 2020-12-10 | — | 83.12 | 0.87 | — | — | — | 0.11 | ok |
| 7DSQ_B | Q01650 | Large neutral amino acids transporter smal | EM | 3.40 | 2020-12-31 | — | 85.88 | 0.88 | — | — | — | 0.10 | ok |
| 7KZQ_C | Q00597 | Fanconi anemia group C protein | EM | 4.30 | 2020-12-10 | — | 82.06 | 0.88 | — | — | — | 0.10 | ok |
| 7KZR_C | Q00597 | Fanconi anemia group C protein | EM | 4.40 | 2020-12-10 | — | 82.06 | 0.88 | — | — | — | 0.10 | ok |
| 7KZS_C | Q00597 | Fanconi anemia group C protein | EM | 4.20 | 2020-12-10 | — | 82.06 | 0.88 | — | — | — | 0.10 | ok |
| 7KZV_C | Q00597 | Fanconi anemia group C protein | EM | 4.20 | 2020-12-10 | — | 82.06 | 0.88 | — | — | — | 0.10 | ok |
| 7KZT_C | Q00597 | Fanconi anemia group C protein | EM | 4.20 | 2020-12-10 | — | 82.06 | 0.88 | — | — | — | 0.10 | ok |
| 7KZP_C | Q00597 | Fanconi anemia group C protein | EM | 3.10 | 2020-12-10 | — | 82.06 | 0.88 | — | — | — | 0.10 | ok |
| 7DTW_A | P41180 | Extracellular calcium-sensing receptor | EM | 4.50 | 2021-01-06 | — | 75.69 | 0.88 | — | — | — | 0.09 | ok |
| 7LFT_A | P29973 | cGMP-gated cation channel alpha-1 | EM | 2.60 | 2021-01-18 | — | 76.25 | 0.88 | — | — | — | 0.09 | ok |
| 7DSN_B | Q01650 | Large neutral amino acids transporter smal | EM | 3.10 | 2020-12-31 | — | 85.88 | 0.90 | — | — | — | 0.09 | ok |
| 7CMU_C | P59768 | Guanine nucleotide-binding protein G(I)/G( | EM | 3.00 | 2020-07-29 | — | 89.56 | 0.90 | — | — | — | 0.09 | ok |
| 7DSK_B | Q01650 | Large neutral amino acids transporter smal | EM | 2.90 | 2020-12-31 | — | 85.88 | 0.90 | — | — | — | 0.08 | ok |
| 7DTU_A | P41180 | Extracellular calcium-sensing receptor | EM | 4.40 | 2021-01-06 | — | 75.69 | 0.89 | — | — | — | 0.08 | ok |
| 6X6C_E | Q9C000 | NACHT, LRR and PYD domains-containing prot | EM | 2.90 | 2020-05-27 | — | 68.25 | 0.88 | — | — | — | 0.08 | ok |
| 7DSL_B | Q01650 | Large neutral amino acids transporter smal | EM | 2.90 | 2020-12-31 | — | 85.88 | 0.90 | — | — | — | 0.08 | ok |
| 6X6A_B | Q9C000 | NACHT, LRR and PYD domains-containing prot | EM | 3.60 | 2020-05-27 | — | 68.25 | 0.88 | — | — | — | 0.08 | ok |
| 7KXY_B | P12259 | Coagulation factor Va | EM | 4.40 | 2020-12-05 | — | 61.91 | 0.87 | — | — | — | 0.08 | ok |
| 6XOG_C | P63165 | Small ubiquitin-related modifier 1 | X-ray | 1.98 | 2020-07-07 | — | 78.31 | 0.90 | — | — | — | 0.08 | ok |
| 7CMV_C | P59768 | Guanine nucleotide-binding protein G(I)/G( | EM | 2.70 | 2020-07-29 | — | 89.56 | 0.93 | — | — | — | 0.07 | ok |
| 7LG1_A | P29973 | cGMP-gated cation channel alpha-1 | EM | 2.70 | 2021-01-19 | — | 76.25 | 0.92 | — | — | — | 0.06 | ok |
| 7LFY_A | P29973 | cGMP-gated cation channel alpha-1 | EM | 3.60 | 2021-01-19 | — | 76.25 | 0.92 | — | — | — | 0.06 | ok |
| 7LFX_A | P29973 | cGMP-gated cation channel alpha-1 | EM | 3.10 | 2021-01-19 | — | 76.25 | 0.92 | — | — | — | 0.06 | ok |
| 7LFW_A | P29973 | cGMP-gated cation channel alpha-1 | EM | 2.90 | 2021-01-18 | — | 76.25 | 0.92 | — | — | — | 0.06 | ok |
| 6M4I_A | Q02224 | Centromere-associated protein E | X-ray | 1.90 | 2020-03-07 | 1.80 | 86.21 | 0.95 | 0.89 | 90.11 | 2.43 | 0.06 | ok |
| 6M4R_A | P02768 | Serum albumin | X-ray | 2.49 | 2020-03-09 | 0.00 | 95.12 | 0.98 | 0.94 | 91.62 | 1.19 | 0.06 | ok |
| 7KXY_A | P12259 | Coagulation factor Va | EM | 4.40 | 2020-12-05 | — | 61.91 | 0.91 | — | — | — | 0.05 | ok |
| 7K3I_A | P50120 | Retinol-binding protein 2 | X-ray | 1.20 | 2020-09-11 | — | 96.50 | 0.95 | — | — | — | 0.05 | ok |
| 6XFP_A | P15056 | Serine/threonine-protein kinase B-raf | X-ray | 2.00 | 2020-06-16 | — | 66.38 | 0.93 | — | — | — | 0.05 | ok |
| 6M1K_A | Q93009 | Ubiquitin carboxyl-terminal hydrolase 7 | X-ray | 2.25 | 2020-02-26 | 0.00 | 91.95 | 0.97 | 0.92 | 91.72 | 1.32 | 0.05 | ok |
| 7KVE_B | P12259 | Coagulation factor V | EM | 3.30 | 2020-11-27 | — | 61.91 | 0.92 | — | — | — | 0.05 | ok |
| 7NDL_A | Q06210 | Isoform 2 of Glutamine-fructose-6-phosphat | X-ray | 2.22 | 2021-02-02 | — | 92.88 | 0.95 | — | — | — | 0.05 | ok |
| 7K36_H | Q9Y3A3 | MOB-like protein phocein | EM | 3.30 | 2020-09-10 | — | 90.81 | 0.95 | — | — | — | 0.04 | ok |
| 7LD0_A | Q6SZW1 | NAD(+) hydrolase SARM1 | EM | 3.10 | 2021-01-12 | — | 85.69 | 0.95 | — | — | — | 0.04 | ok |
| 6UGK_A | Q9H6P5 | Threonine aspartase 1,Threonine aspartase | X-ray | 2.15 | 2019-09-26 | 0.00 | 95.77 | 0.54 | 0.94 | 95.31 | 2.19 | 0.04 | ok |
| 7LMT_A | O96028 | Histone-lysine N-methyltransferase NSD2 | X-ray | 2.27 | 2021-02-05 | — | 65.62 | 0.94 | — | — | — | 0.04 | ok |
| 7KZR_X | Q9NPD8 | Ubiquitin-conjugating enzyme E2 T | EM | 4.40 | 2020-12-10 | — | 86.25 | 0.96 | — | — | — | 0.04 | ok |
| 7K36_I | Q5VSL9 | Striatin-interacting protein 1 | EM | 3.30 | 2020-09-10 | — | 80.88 | 0.95 | — | — | — | 0.04 | ok |
| 7JW7_A | Q8NB16 | Mixed lineage kinase domain-like protein | X-ray | 2.63 | 2020-08-25 | — | 83.12 | 0.96 | — | — | — | 0.04 | ok |
| 7KZV_X | Q9NPD8 | Ubiquitin-conjugating enzyme E2 T | EM | 4.20 | 2020-12-10 | — | 86.25 | 0.96 | — | — | — | 0.04 | ok |
| 7KZT_X | Q9NPD8 | Ubiquitin-conjugating enzyme E2 T | EM | 4.20 | 2020-12-10 | — | 86.25 | 0.96 | — | — | — | 0.03 | ok |
| 7KZS_X | Q9NPD8 | Ubiquitin-conjugating enzyme E2 T | EM | 4.20 | 2020-12-10 | — | 86.25 | 0.96 | — | — | — | 0.03 | ok |
| 7B51_B | P62826 | GTP-binding nuclear protein Ran | X-ray | 2.58 | 2020-12-03 | — | 88.62 | 0.97 | — | — | — | 0.03 | ok |
| 7JWR_A | P50120 | Retinol-binding protein 2 | X-ray | 1.30 | 2020-08-26 | — | 96.50 | 0.97 | — | — | — | 0.03 | ok |
| 7AD6_A | P01031 | Complement C5 | X-ray | 2.75 | 2020-09-14 | — | 81.56 | 0.97 | — | — | — | 0.03 | ok |
| 7JX2_A | P50120 | Retinol-binding protein 2 | X-ray | 1.80 | 2020-08-26 | — | 96.50 | 0.97 | — | — | — | 0.03 | ok |
| 6YF2_A | P62942 | Peptidyl-prolyl cis-trans isomerase FKBP1A | X-ray | 1.03 | 2020-03-25 | — | 96.25 | 0.97 | — | — | — | 0.03 | ok |
| 6YF3_A | P62942 | Peptidyl-prolyl cis-trans isomerase FKBP1A | X-ray | 1.00 | 2020-03-25 | — | 96.25 | 0.97 | — | — | — | 0.03 | ok |
| 7DUO_B | P28907 | ADP-ribosyl cyclase/cyclic ADP-ribose hydr | X-ray | 2.81 | 2021-01-10 | — | 90.88 | 0.97 | — | — | — | 0.03 | ok |
| 7JWD_A | P50120 | Retinol-binding protein 2 | X-ray | 1.35 | 2020-08-25 | — | 96.50 | 0.97 | — | — | — | 0.03 | ok |
| 7LWB_A | P61006 | Ras-related protein Rab-8A | X-ray | 1.90 | 2021-02-28 | — | 85.44 | 0.97 | — | — | — | 0.02 | ok |
| 7BEQ_A | Q99836 | Myeloid differentiation primary response p | EM | 3.00 | 2020-12-24 | — | 80.56 | 0.97 | — | — | — | 0.02 | ok |
| 7DSN_A | P08195 | 4F2 cell-surface antigen heavy chain | EM | 3.10 | 2020-12-31 | — | 78.69 | 0.97 | — | — | — | 0.02 | ok |
| 7DSQ_A | P08195 | 4F2 cell-surface antigen heavy chain | EM | 3.40 | 2020-12-31 | — | 78.69 | 0.97 | — | — | — | 0.02 | ok |
| 7DSL_A | P08195 | 4F2 cell-surface antigen heavy chain | EM | 2.90 | 2020-12-31 | — | 78.69 | 0.98 | — | — | — | 0.02 | ok |
| 7JVG_A | P50120 | Retinol-binding protein 2 | X-ray | 1.40 | 2020-08-21 | — | 96.50 | 0.98 | — | — | — | 0.02 | ok |
| 7DSK_A | P08195 | 4F2 cell-surface antigen heavy chain | EM | 2.90 | 2020-12-31 | — | 78.69 | 0.98 | — | — | — | 0.02 | ok |
| 7AEL_AAA | P01009 | Alpha-1-antitrypsin | X-ray | 1.76 | 2020-09-17 | — | 88.62 | 0.98 | — | — | — | 0.02 | ok |
| 7L6W_A | Q99836 | Myeloid differentiation primary response p | X-ray | 2.30 | 2020-12-24 | — | 80.56 | 0.98 | — | — | — | 0.02 | ok |
| 7JZ5_A | P50120 | Retinol-binding protein 2 | X-ray | 1.57 | 2020-09-01 | — | 96.50 | 0.98 | — | — | — | 0.02 | ok |
| 7KPL_A | P54762 | Ephrin type-B receptor 1 | X-ray | 2.71 | 2020-11-11 | — | 83.62 | 0.98 | — | — | — | 0.02 | ok |
| 7BER_A | Q99836 | Myeloid differentiation primary response p | X-ray | 2.30 | 2020-12-24 | — | 80.56 | 0.98 | — | — | — | 0.02 | ok |
| 6W12_A | Q8IUN9 | C-type lectin domain family 10 member A | X-ray | 2.00 | 2020-03-03 | — | 80.44 | 0.98 | — | — | — | 0.02 | ok |
| 6YF1_A | P62942 | Peptidyl-prolyl cis-trans isomerase FKBP1A | X-ray | 1.12 | 2020-03-25 | — | 96.25 | 0.98 | — | — | — | 0.02 | ok |
| 7JVY_A | P50120 | Retinol-binding protein 2 | X-ray | 1.30 | 2020-08-24 | — | 96.50 | 0.98 | — | — | — | 0.02 | ok |
| 7LBG_D | Q03167 | Transforming growth factor beta receptor t | EM | 2.60 | 2021-01-07 | — | 71.00 | 0.98 | — | — | — | 0.02 | ok |
| 6XOG_B | Q9UBT2 | SUMO-activating enzyme subunit 2 | X-ray | 1.98 | 2020-07-07 | — | 85.25 | 0.98 | — | — | — | 0.02 | ok |
| 7DCZ_A | P56817 | Beta-secretase 1 | X-ray | 2.30 | 2020-10-27 | — | 87.50 | 0.98 | — | — | — | 0.02 | ok |
| 7KPM_A | P54762 | Ephrin type-B receptor 1 | X-ray | 1.61 | 2020-11-11 | — | 83.62 | 0.98 | — | — | — | 0.02 | ok |
| 7K36_B | Q13033 | Striatin-3 | EM | 3.30 | 2020-09-10 | — | 67.50 | 0.98 | — | — | — | 0.02 | ok |
| 6WPE_A | P14902 | Indoleamine 2,3-dioxygenase 1 | X-ray | 2.43 | 2020-04-27 | — | 93.06 | 0.98 | — | — | — | 0.01 | ok |
| 6XOG_A | Q9UBE0 | SUMO-activating enzyme subunit 1 | X-ray | 1.98 | 2020-07-07 | — | 91.44 | 0.99 | — | — | — | 0.01 | ok |
| 6YF0_A | P62942 | Peptidyl-prolyl cis-trans isomerase FKBP1A | X-ray | 1.55 | 2020-03-25 | — | 96.25 | 0.99 | — | — | — | 0.01 | ok |
| 7K36_C | P67775 | Serine/threonine-protein phosphatase 2A ca | EM | 3.30 | 2020-09-10 | — | 95.06 | 0.99 | — | — | — | 0.01 | ok |
| 7AD7_A | P01031 | Complement C5 | X-ray | 2.30 | 2020-09-14 | — | 81.56 | 0.99 | — | — | — | 0.01 | ok |
| 6WHE_A | P61006 | Ras-related protein Rab-8A | X-ray | 1.73 | 2020-04-08 | — | 85.44 | 0.99 | — | — | — | 0.01 | ok |
| 6X6C_A | Q86TI2 | Dipeptidyl peptidase 9 | EM | 2.90 | 2020-05-27 | — | 92.50 | 0.99 | — | — | — | 0.01 | ok |
| 7CMU_B | P62873 | Guanine nucleotide-binding protein G(I)/G( | EM | 3.00 | 2020-07-29 | — | 97.06 | 0.99 | — | — | — | 0.01 | ok |
| 6X6A_A | Q86TI2 | Dipeptidyl peptidase 9 | EM | 3.60 | 2020-05-27 | — | 92.50 | 0.99 | — | — | — | 0.01 | ok |
| 7CMV_B | P62873 | Guanine nucleotide-binding protein G(I)/G( | EM | 2.70 | 2020-07-29 | — | 97.06 | 0.99 | — | — | — | 0.01 | ok |
| 7B51_A | O14980 | Exportin-1 | X-ray | 2.58 | 2020-12-03 | — | 91.44 | 0.99 | — | — | — | 0.01 | ok |
| 7KJ0_A | P32119 | Peroxiredoxin-2 | X-ray | 2.29 | 2020-10-25 | — | 97.75 | 1.00 | — | — | — | 0.00 | ok |
| 7KJ1_A | P32119 | Peroxiredoxin-2 | X-ray | 2.15 | 2020-10-25 | — | 97.75 | 1.00 | — | — | — | 0.00 | ok |
| 7KIZ_A | P32119 | Peroxiredoxin-2 | X-ray | 1.70 | 2020-10-25 | — | 97.75 | 1.00 | — | — | — | 0.00 | ok |
| 6ZYF_A | Q6P988 | Palmitoleoyl-protein carboxylesterase NOTU | X-ray | 2.19 | 2020-07-31 | — | 83.94 | 1.00 | — | — | — | 0.00 | ok |
| 7KEN_A | P18031 | Tyrosine-protein phosphatase non-receptor | X-ray | 1.80 | 2020-10-11 | — | 81.25 | 1.00 | — | — | — | 0.00 | ok |
| 7KG0_A | Q86W56 | Poly(ADP-ribose) glycohydrolase | X-ray | 1.66 | 2020-10-15 | — | 68.25 | 1.00 | — | — | — | 0.00 | ok |
| 7KG8_A | Q86W56 | Poly(ADP-ribose) glycohydrolase | X-ray | 1.43 | 2020-10-16 | — | 68.25 | 1.00 | — | — | — | 0.00 | ok |
| 7KG1_A | Q86W56 | Poly(ADP-ribose) glycohydrolase | X-ray | 1.65 | 2020-10-15 | — | 68.25 | 1.00 | — | — | — | 0.00 | ok |
| 7KG6_A | Q86W56 | Poly(ADP-ribose) glycohydrolase | X-ray | 1.96 | 2020-10-16 | — | 68.25 | 1.00 | — | — | — | 0.00 | ok |
| 7KFP_A | Q86W56 | Poly(ADP-ribose) glycohydrolase | X-ray | 1.90 | 2020-10-14 | — | 68.25 | 1.00 | — | — | — | 0.00 | ok |
| 7KG7_A | Q86W56 | Poly(ADP-ribose) glycohydrolase | X-ray | 1.85 | 2020-10-16 | — | 68.25 | 1.00 | — | — | — | 0.00 | ok |
Click a column header to sort. FRAUD = confidence-weighted error; a structure is flagged confidently wrong when mean pLDDT > 70 yet TM-score < 0.5.