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8XWW_A

Isoform PDE5A1 of cGMP-specific 3',5'-cyclic phosphodiesterase · O76074 · RCSB 8XWW · AF-O76074-F1 (v6)

Screen-only record. This structure passed the fast TM-score screen (TM 0.98) and AlphaFold agrees well with experiment, so the full metric suite, novelty score and heatmaps were not computed. Full analysis is reserved for the disagreements (TM below the screening threshold).

0.98

TM-score

lDDT

Cα-RMSD Å

82.00

mean pLDDT

0.02

FRAUD score

—%

novelty

All metrics

Global fold agreement

TM-score (norm. experiment)	0.98
TM-score (norm. model)	0.33
TM-score (norm. shorter)	0.98
TM-score (norm. longer)	0.33

Local, superposition-free

Backbone & secondary structure

Confidence calibration

mean pLDDT

82.00

Context & headline

FRAUD score

0.02

Deposited 2024-01-16 · released 2025-01-22 · X-ray · 2.46 Å · closest pre-cutoff chain: none