new PDB depositions vs. their blind AlphaFold predictions — a running test of "is folding solved?"

36AD_A

Fumarate hydratase, mitochondrial · P07954 · RCSB 36AD · AF-P07954-F1 (v6)

0.9982
TM-score
0.9957
lDDT
0.481
Cα-RMSD Å
98.25
mean pLDDT
0.0183
FRAUD score
100.0%
novelty (max id)

Per-domain breakdown

SourceDomainRangeResiduesTMRMSD Åmean Cα ΔName
PAEPAE:1-5101-510 4560.9972 0.4810.284

All metrics

Global fold agreement

TM-score (norm. experiment)0.9982
TM-score (norm. model)0.8927
TM-score (norm. shorter)0.9982
TM-score (norm. longer)0.8927
Cα-RMSD (Å)0.481
backbone-RMSD (Å)0.525
all-atom-RMSD (Å)0.717
core-RMSD (Å)0.313
core fraction0.998
GDT_TS99.78
GDT_HA97.37
MaxSub0.9983
structural overlap (3.5 Å)0.9978

Local, superposition-free

lDDT0.9957
contact-map Jaccard0.9449
contact precision0.9647
contact recall0.9788
distance-matrix mean Δ (Å)0.178
CAD-score (approx)0.2779

Backbone & secondary structure

SS agreement Q3 (%)96.71
mean Δφ (°)4.9
mean Δψ (°)5.5
torsion within 30° (frac)0.989
Rg experiment (Å)30.3
Rg model (Å)30.23
ΔRg (Å)0.06

Confidence calibration

mean pLDDT98.25
pLDDT↔lDDT Pearson0.7062
pLDDT↔lDDT Spearman0.3386
PAE↔observed Pearson0.3388
PAE overconfident frac0.0003
mean PAE (Å)3.037
mean observed error (Å)0.178

Context & headline

coverage of model0.8941
coverage of experiment1.0
seq identity aligned (%)100.0
confidently-wrong residue frac0.0022
FRAUD score0.0183

Deposited 2026-05-27 · released 2026-06-10 · X-ray · 2.11 Å · closest pre-cutoff chain: 3E04_1