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new PDB depositions vs. their blind AlphaFold predictions — a running test of "is folding solved?"

30KH_A

Transient receptor potential cation channel subfamily M member 4 · Q8TD43 · RCSB 30KH · AF-Q8TD43-F1 (v6)

0.8051

TM-score

0.813

lDDT

6.499

Cα-RMSD Å

84.6

mean pLDDT

0.3126

FRAUD score

100.0%

novelty (max id)

Per-domain breakdown

Source	Domain	Range	Residues	TM	RMSD Å	mean Cα Δ	Name
PAE	PAE:1-1214	1-1214	990	0.7753	6.499	5.668

All metrics

Global fold agreement

TM-score (norm. experiment)	0.8051
TM-score (norm. model)	0.6713
TM-score (norm. shorter)	0.8051
TM-score (norm. longer)	0.6713
Cα-RMSD (Å)	6.499
backbone-RMSD (Å)	6.469
all-atom-RMSD (Å)	6.601
core-RMSD (Å)	1.224
core fraction	0.282
GDT_TS	30.91
GDT_HA	10.08
MaxSub	0.9445
structural overlap (3.5 Å)	0.2444

Local, superposition-free

lDDT	0.813
contact-map Jaccard	0.624
contact precision	0.7332
contact recall	0.8074
distance-matrix mean Δ (Å)	3.337
CAD-score (approx)	0.2995

Backbone & secondary structure

SS agreement Q3 (%)	91.72
mean Δφ (°)	17.4
mean Δψ (°)	21.4
torsion within 30° (frac)	0.7525
Rg experiment (Å)	46.12
Rg model (Å)	45.71
ΔRg (Å)	0.41

Confidence calibration

mean pLDDT	84.6
pLDDT↔lDDT Pearson	0.6153
pLDDT↔lDDT Spearman	0.4273
PAE↔observed Pearson	0.5625
PAE overconfident frac	0.0006
mean PAE (Å)	14.718
mean observed error (Å)	3.334

Context & headline

coverage of model	0.8155
coverage of experiment	1.0
seq identity aligned (%)	100.0
confidently-wrong residue frac	0.598
FRAUD score	0.3126

Deposited 2026-04-30 · released 2026-06-24 · EM · 3.7 Å · closest pre-cutoff chain: 5WP6_1