new PDB depositions vs. their blind AlphaFold predictions — a running test of "is folding solved?"

26LK_C novel

Polynucleotide 5'-hydroxyl-kinase NOL9 · Q5SY16 · RCSB 26LK · AF-Q5SY16-F1 (v6)

0.9712
TM-score
0.8749
lDDT
1.938
Cα-RMSD Å
90.78
mean pLDDT
0.0597
FRAUD score
24.6%
novelty (max id)

Per-domain breakdown

SourceDomainRangeResiduesTMRMSD Åmean Cα ΔName
PAEPAE:1-7021-702 5230.9715 1.9381.115

All metrics

Global fold agreement

TM-score (norm. experiment)0.9712
TM-score (norm. model)0.7269
TM-score (norm. shorter)0.9712
TM-score (norm. longer)0.7269
Cα-RMSD (Å)1.938
backbone-RMSD (Å)1.92
all-atom-RMSD (Å)2.4
core-RMSD (Å)0.831
core fraction0.881
GDT_TS88.53
GDT_HA70.27
MaxSub0.9811
structural overlap (3.5 Å)0.9751

Local, superposition-free

lDDT0.8749
contact-map Jaccard0.7934
contact precision0.8756
contact recall0.8942
distance-matrix mean Δ (Å)0.802
CAD-score (approx)0.8502

Backbone & secondary structure

SS agreement Q3 (%)88.72
mean Δφ (°)18.2
mean Δψ (°)20.3
torsion within 30° (frac)0.7208
Rg experiment (Å)25.3
Rg model (Å)25.33
ΔRg (Å)0.03

Confidence calibration

mean pLDDT90.78
pLDDT↔lDDT Pearson0.7022
pLDDT↔lDDT Spearman0.6492
PAE↔observed Pearson0.5091
PAE overconfident frac0.0001
mean PAE (Å)6.357
mean observed error (Å)0.801

Context & headline

coverage of model0.745
coverage of experiment1.0
seq identity aligned (%)100.0
confidently-wrong residue frac0.0076
FRAUD score0.0597

Deposited 2026-05-06 · released 2026-06-03 · EM · 3.4 Å · closest pre-cutoff chain: 4OHV_1