new PDB depositions vs. their blind AlphaFold predictions — a running test of "is folding solved?"

13IO_E

Calcium uniporter protein, mitochondrial · Q8NE86 · RCSB 13IO · AF-Q8NE86-F1 (v6)

0.8535
TM-score
0.9345
lDDT
3.946
Cα-RMSD Å
90.79
mean pLDDT
0.1765
FRAUD score
45.3%
novelty (max id)

Per-domain breakdown

SourceDomainRangeResiduesTMRMSD Åmean Cα ΔName
PAEPAE:1-3511-351 1710.7582 3.9463.01

All metrics

Global fold agreement

TM-score (norm. experiment)0.8535
TM-score (norm. model)0.4269
TM-score (norm. shorter)0.8535
TM-score (norm. longer)0.4269
Cα-RMSD (Å)3.946
backbone-RMSD (Å)3.837
all-atom-RMSD (Å)4.365
core-RMSD (Å)0.555
core fraction0.708
GDT_TS55.99
GDT_HA32.6
MaxSub0.857
structural overlap (3.5 Å)0.7895

Local, superposition-free

lDDT0.9345
contact-map Jaccard0.6711
contact precision0.8644
contact recall0.75
distance-matrix mean Δ (Å)1.494
CAD-score (approx)0.8884

Backbone & secondary structure

SS agreement Q3 (%)98.83
mean Δφ (°)10.8
mean Δψ (°)13.4
torsion within 30° (frac)0.8889
Rg experiment (Å)31.36
Rg model (Å)30.11
ΔRg (Å)1.26

Confidence calibration

mean pLDDT90.79
pLDDT↔lDDT Pearson0.7366
pLDDT↔lDDT Spearman0.6286
PAE↔observed Pearson0.716
PAE overconfident frac0.0004
mean PAE (Å)6.986
mean observed error (Å)1.485

Context & headline

coverage of model0.4872
coverage of experiment1.0
seq identity aligned (%)100.0
confidently-wrong residue frac0.1404
FRAUD score0.1765

Deposited 2026-05-07 · released 2026-07-08 · EM · 2.98 Å · closest pre-cutoff chain: 5ID3_1