new PDB depositions vs. their blind AlphaFold predictions — a running test of "is folding solved?"

13GH_C

IST1 homolog · P53990 · RCSB 13GH · AF-P53990-F1 (v6)

0.9664
TM-score
0.9623
lDDT
0.997
Cα-RMSD Å
93.89
mean pLDDT
0.0526
FRAUD score
100.0%
novelty (max id)

Per-domain breakdown

SourceDomainRangeResiduesTMRMSD Åmean Cα ΔName
PAEPAE:1-3641-364 1860.9658 0.9970.861

All metrics

Global fold agreement

TM-score (norm. experiment)0.9664
TM-score (norm. model)0.5013
TM-score (norm. shorter)0.9664
TM-score (norm. longer)0.5013
Cα-RMSD (Å)0.997
backbone-RMSD (Å)0.972
all-atom-RMSD (Å)1.43
core-RMSD (Å)0.866
core fraction0.973
GDT_TS93.15
GDT_HA72.72
MaxSub0.9677
structural overlap (3.5 Å)0.9946

Local, superposition-free

lDDT0.9623
contact-map Jaccard0.8164
contact precision0.9086
contact recall0.8895
distance-matrix mean Δ (Å)0.384
CAD-score (approx)0.2602

Backbone & secondary structure

SS agreement Q3 (%)93.01
mean Δφ (°)6.4
mean Δψ (°)7.9
torsion within 30° (frac)0.9731
Rg experiment (Å)19.91
Rg model (Å)20.09
ΔRg (Å)0.18

Confidence calibration

mean pLDDT93.89
pLDDT↔lDDT Pearson0.6521
pLDDT↔lDDT Spearman0.2609
PAE↔observed Pearson0.5145
PAE overconfident frac0.0
mean PAE (Å)5.014
mean observed error (Å)0.382

Context & headline

coverage of model0.511
coverage of experiment1.0
seq identity aligned (%)100.0
confidently-wrong residue frac0.0
FRAUD score0.0526

Deposited 2026-05-05 · released 2026-07-08 · EM · 2.56 Å · closest pre-cutoff chain: 3FRR_1