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new PDB depositions vs. their blind AlphaFold predictions — a running test of "is folding solved?"

13CM_G

Prothrombin · P00734 · RCSB 13CM · AF-P00734-F1 (v6)

0.8682

TM-score

0.8574

lDDT

1.419

Cα-RMSD Å

81.76

mean pLDDT

0.0541

FRAUD score

100.0%

novelty (max id)

Per-domain breakdown

Source	Domain	Range	Residues	TM	RMSD Å	mean Cα Δ	Name
PAE	PAE:1-622	1-622	62	0.8511	1.419	1.092

All metrics

Global fold agreement

TM-score (norm. experiment)	0.8682
TM-score (norm. model)	0.0966
TM-score (norm. shorter)	0.8682
TM-score (norm. longer)	0.0966
Cα-RMSD (Å)	1.419
backbone-RMSD (Å)	1.368
all-atom-RMSD (Å)	1.828
core-RMSD (Å)	0.677
core fraction	0.839
GDT_TS	88.71
GDT_HA	66.94
MaxSub	0.8708
structural overlap (3.5 Å)	0.9677

Local, superposition-free

lDDT	0.8574
contact-map Jaccard	0.7619
contact precision	0.8205
contact recall	0.9143
distance-matrix mean Δ (Å)	0.65
CAD-score (approx)	0.8143

Backbone & secondary structure

SS agreement Q3 (%)	83.87
mean Δφ (°)	23.3
mean Δψ (°)	20.4
torsion within 30° (frac)	0.6774
Rg experiment (Å)	11.47
Rg model (Å)	11.36
ΔRg (Å)	0.12

Confidence calibration

mean pLDDT	81.76
pLDDT↔lDDT Pearson	0.7564
pLDDT↔lDDT Spearman	0.4807
PAE↔observed Pearson	0.5545
PAE overconfident frac	0.0
mean PAE (Å)	5.552
mean observed error (Å)	0.639

Context & headline

coverage of model	0.0997
coverage of experiment	1.0
seq identity aligned (%)	83.87
confidently-wrong residue frac	0.0
FRAUD score	0.0541

Deposited 2026-04-29 · released 2026-07-08 · EM · 3.2 Å · closest pre-cutoff chain: 4NZQ_1