new PDB depositions vs. their blind AlphaFold predictions — a running test of "is folding solved?"

13BV_A novel

Phosphoinositide 3-kinase regulatory subunit 4 · Q99570 · RCSB 13BV · AF-Q99570-F1 (v6)

0.6556
TM-score
0.8978
lDDT
17.059
Cα-RMSD Å
85.43
mean pLDDT
0.689
FRAUD score
26.3%
novelty (max id)

Per-domain breakdown

SourceDomainRangeResiduesTMRMSD Åmean Cα ΔName
PAEPAE:1-13581-1358 11530.4162 17.05915.382

All metrics

Global fold agreement

TM-score (norm. experiment)0.6556
TM-score (norm. model)0.5588
TM-score (norm. shorter)0.6556
TM-score (norm. longer)0.5588
Cα-RMSD (Å)17.059
backbone-RMSD (Å)17.059
all-atom-RMSD (Å)17.076
core-RMSD (Å)0.757
core fraction0.241
GDT_TS5.14
GDT_HA0.98
MaxSub0.942
structural overlap (3.5 Å)0.026

Local, superposition-free

lDDT0.8978
contact-map Jaccard0.8087
contact precision0.9049
contact recall0.8838
distance-matrix mean Δ (Å)8.027
CAD-score (approx)0.8443

Backbone & secondary structure

SS agreement Q3 (%)90.2
mean Δφ (°)15.3
mean Δψ (°)16.5
torsion within 30° (frac)0.7944
Rg experiment (Å)50.49
Rg model (Å)48.59
ΔRg (Å)1.9

Confidence calibration

mean pLDDT85.43
pLDDT↔lDDT Pearson0.6487
pLDDT↔lDDT Spearman0.6162
PAE↔observed Pearson0.5829
PAE overconfident frac0.0852
mean PAE (Å)18.697
mean observed error (Å)8.02

Context & headline

coverage of model0.849
coverage of experiment1.0
seq identity aligned (%)100.0
confidently-wrong residue frac0.8803
FRAUD score0.689

Deposited 2026-04-28 · released 2026-05-13 · EM · 3.77 Å · closest pre-cutoff chain: 5KC2_2